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学科主题: 临床医学
题名:
Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT
作者: Zhao, Xiao-Su; Liu, Kai-Yan; Liu, Dai-Hong; Xu, Lan-Ping; Chen, Huan; Huang, Xiao-Jun
关键词: acute graft-versus-host disease ; allogeneic hematopoietic stem cell transplantation ; immunosuppressive ; indoleamine 2 ; 3-dioxygenase
刊名: CLINICAL TRANSPLANTATION
发表日期: 2011-05-01
DOI: 10.1111/j.1399-0012.2011.01416.x
卷: 25, 期:3, 页:E304-E311
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; VERSUS-HOST-DISEASE ; TRYPTOPHAN CATABOLISM ; DENDRITIC CELLS ; IFN-GAMMA ; ALLOGRAFT-REJECTION ; EXPRESSION ; DEGRADATION ; TOLERANCE ; MECHANISM
英文摘要:

Given the function of indoleamine 2,3-dioxygenase (IDO) in the induction of immune tolerance as a T-cell inhibitor, we investigated whether plasma IDO levels correlate with the biological activity of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Plasma levels of IDO were monitored by ELISA in 147 samples from 65 patients who fulfilled the diagnostic histopathological and/or clinical criteria of aGVHD and 16 episodes of infection after allo-HSCT. Elevated plasma IDO levels were associated with occurrence of infection or mild aGVHD (grade I-II). Most patients with grade III-IV aGVHD had relatively low levels of IDO compared to those with mild aGVHD or infection. Responses of aGVHD to immunosuppressive therapy were associated with a decrease in IDO levels in the majority of patients with mild aGVHD, whereas secondary infection was characterized by persistent or increased IDO levels after treatment. Although plasma IDO levels may indicate the severity and outcome of aGVHD and point to appropriate therapies through its function in immune tolerance, it is not aGVHD specific and may not be a distinguishing biomarker of aGVHD.

语种: 英语
WOS记录号: WOS:000291226000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64163
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, BMT, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Xiao-Su,Liu, Kai-Yan,Liu, Dai-Hong,et al. Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT[J]. CLINICAL TRANSPLANTATION,2011,25(3):E304-E311.
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