IR@PKUHSC  > 北京大学基础医学院  > 北京大学感染病研究中心
学科主题基础医学
14-3-3 gamma and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia
Dong, Yan3,4,5,6; Zhao, Rui3,4,5,6; Chen, Xiao Qian2; Yu, Albert Cheung Hoi1,3,4,5,6
关键词Intrinsic protective protein Stroke Preconditioning 14-3-3 gamma Neuroglobin
刊名MOLECULAR NEUROBIOLOGY
2010-06-01
DOI10.1007/s12035-010-8142-4
41期:2-3页:218-231
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program)
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NF-KAPPA-B ; TISSUE-PLASMINOGEN ACTIVATOR ; COLONY-STIMULATING FACTOR ; THERAPEUTIC TIME WINDOW ; IMMEDIATE-EARLY GENE ; IN-VITRO ISCHEMIA ; BRAIN-INJURY ; OXIDATIVE STRESS ; ARTERY OCCLUSION ; ACUTE STROKE
英文摘要

A number of intrinsic factors are present intracellularly and could be turned on to protect cells from stress and injury, including cerebral ischemia. The degree of protection of these factors is dependent on the time of induction, their concentration, as well as the duration and extent of injury. This review summarizes recent studies on some of the protective factors with specific emphasis on two recently discovered intrinsic protective proteins: 14-3-3 gamma protein and neuroglobin. Both of them were originally discovered in neurons, later identified in astrocytes under ischemic conditions, and demonstrated to have protective effect on nerve cells from apoptosis. Understanding the mode of induction and role of protection of these intrinsic protective proteins would be beneficial for the future development of pharmacotherapy in extending the therapeutic time window, which would lead to better stroke management for patients.

语种英语
所属项目编号30270426 ; 30470543 ; 30670644 ; 30870818 ; 7032026 ; 7051004 ; 7091004 ; 2006AA02Z452
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program)
WOS记录号WOS:000278095800017
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64165
Collection北京大学基础医学院_北京大学感染病研究中心
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China
3.Huazhong Univ Sci & Technol, Key Lab Neurol Dis, Minist Educ, Wuhan 400030, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Peking Univ, Key Lab Neurosci, Minist Publ Hlth, Beijing 100191, Peoples R China
6.Peking Univ, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Dong, Yan,Zhao, Rui,Chen, Xiao Qian,et al. 14-3-3 gamma and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia[J]. MOLECULAR NEUROBIOLOGY,2010,41(2-3):218-231.
APA Dong, Yan,Zhao, Rui,Chen, Xiao Qian,&Yu, Albert Cheung Hoi.(2010).14-3-3 gamma and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia.MOLECULAR NEUROBIOLOGY,41(2-3),218-231.
MLA Dong, Yan,et al."14-3-3 gamma and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia".MOLECULAR NEUROBIOLOGY 41.2-3(2010):218-231.
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