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学科主题: 基础医学
题名:
14-3-3 gamma and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia
作者: Dong, Yan3,4,5,6; Zhao, Rui3,4,5,6; Chen, Xiao Qian2; Yu, Albert Cheung Hoi1,3,4,5,6
关键词: Intrinsic protective protein ; Stroke ; Preconditioning ; 14-3-3 gamma ; Neuroglobin
刊名: MOLECULAR NEUROBIOLOGY
发表日期: 2010-06-01
DOI: 10.1007/s12035-010-8142-4
卷: 41, 期:2-3, 页:218-231
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NF-KAPPA-B ; TISSUE-PLASMINOGEN ACTIVATOR ; COLONY-STIMULATING FACTOR ; THERAPEUTIC TIME WINDOW ; IMMEDIATE-EARLY GENE ; IN-VITRO ISCHEMIA ; BRAIN-INJURY ; OXIDATIVE STRESS ; ARTERY OCCLUSION ; ACUTE STROKE
英文摘要:

A number of intrinsic factors are present intracellularly and could be turned on to protect cells from stress and injury, including cerebral ischemia. The degree of protection of these factors is dependent on the time of induction, their concentration, as well as the duration and extent of injury. This review summarizes recent studies on some of the protective factors with specific emphasis on two recently discovered intrinsic protective proteins: 14-3-3 gamma protein and neuroglobin. Both of them were originally discovered in neurons, later identified in astrocytes under ischemic conditions, and demonstrated to have protective effect on nerve cells from apoptosis. Understanding the mode of induction and role of protection of these intrinsic protective proteins would be beneficial for the future development of pharmacotherapy in extending the therapeutic time window, which would lead to better stroke management for patients.

语种: 英语
所属项目编号: 30270426 ; 30470543 ; 30670644 ; 30870818 ; 7032026 ; 7051004 ; 7091004 ; 2006AA02Z452
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program)
WOS记录号: WOS:000278095800017
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64165
Appears in Collections:基础医学院_北京大学感染病研究中心_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China
3.Huazhong Univ Sci & Technol, Key Lab Neurol Dis, Minist Educ, Wuhan 400030, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Peking Univ, Key Lab Neurosci, Minist Publ Hlth, Beijing 100191, Peoples R China
6.Peking Univ, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China

Recommended Citation:
Dong, Yan,Zhao, Rui,Chen, Xiao Qian,et al. 14-3-3 gamma and Neuroglobin are New Intrinsic Protective Factors for Cerebral Ischemia[J]. MOLECULAR NEUROBIOLOGY,2010,41(2-3):218-231.
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