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Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease
Liu, Tengfei1; Zhang, Jingwei1; Chen, Xiahuan1; Feng, Xueru1; Fu, Sidney W.2; McCaffrey, Timothy A.2; Liu, Meilin1
关键词Coronary artery disease (CAD) Aspirin 11-Dehydrothromboxane B2 (11dhTxB2) Light Transmission Aggregometry (LTA) High-on aspirin platelet reactivity (HAPR)
刊名GENE
2015-10-15
DOI10.1016/j.gene.2015.06.045
571期:1页:23-27
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
资助者International Science &amp ; Technology Cooperation Projects of China ; National Science &amp ; Technology Pillar Program of China ; Beijing Huikangyisheng Sci-Tech Co., Ltd. ; International Science &amp ; Technology Cooperation Projects of China ; National Science &amp ; Technology Pillar Program of China ; Beijing Huikangyisheng Sci-Tech Co., Ltd.
研究领域[WOS]Genetics & Heredity
关键词[WOS]TYPE-2 DIABETES-MELLITUS ; THROMBOXANE BIOSYNTHESIS ; RESISTANCE ; STROKE ; RISK ; THERAPY ; PREVENTION ; PREVALENCE ; REACTIVITY
英文摘要

Aspirin is widely used in the primary and secondary prevention of cardiovascular diseases. The aim of our study was to compare between two established methods of aspirin response, urinary 11-dehydrothromboxane B2 (11dhTX132) and platelet Light Transmission Aggregometry (LTA) assays in elderly Chinese patients with coronary artery disease (CAD), and to investigate the clinical significance of both methods in predicting cardiovascular events. Urinary 11dhTxB2 assay and arachidonic acid-induced (AA, 0.5 mg/ml) platelet aggregation by Light Transmission Aggregometry (LTA) assay were measured to evaluate aspirin responses. High-on aspirin platelet reactivity (HAPR) was defined as urinary 11dhTxB2 > 1500 pg/mg or AA-induced platelet aggregation >= 15.22%-the upper quartile of our enrolled population. The two tests showed a poor correlation for aspirin inhibition (r = 0.063) and a poor agreement in classifying HAPR (kappa = 0.053). With a mean follow-up time of 12 months, cardiovascular events occurred more frequently in HAPR patients who were diagnosed by LTA assay as compared with no-HAPR patients (22.5% versus 10.6%, P = 0.039, OR = 2.45, 95% CI = 1.06-5.63). However, the HAPR status, as determined by urinary 11dTXB2 measurement, did not show a significant correlation with outcomes. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2013DFA30860 ; 2012BAI 37B00 ; 00020140616003
资助者International Science &amp ; Technology Cooperation Projects of China ; National Science &amp ; Technology Pillar Program of China ; Beijing Huikangyisheng Sci-Tech Co., Ltd. ; International Science &amp ; Technology Cooperation Projects of China ; National Science &amp ; Technology Pillar Program of China ; Beijing Huikangyisheng Sci-Tech Co., Ltd.
WOS记录号WOS:000360420500004
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64172
专题北京大学第一临床医学院_老年病内科
作者单位1.Peking Univ, Dept Geriatr, Hosp 1, Beijing 100034, Peoples R China
2.George Washington Univ, Sch Med & Hlth Sci, Div Genom Med, Dept Med, Washington, DC 20037 USA
推荐引用方式
GB/T 7714
Liu, Tengfei,Zhang, Jingwei,Chen, Xiahuan,et al. Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease[J]. GENE,2015,571(1):23-27.
APA Liu, Tengfei.,Zhang, Jingwei.,Chen, Xiahuan.,Feng, Xueru.,Fu, Sidney W..,...&Liu, Meilin.(2015).Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.GENE,571(1),23-27.
MLA Liu, Tengfei,et al."Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease".GENE 571.1(2015):23-27.
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