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CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK
Huang, J.1,2; Shi, T.1,2,3; Ma, T.1,2; Zhang, Y.1,2; Ma, X.1,2; Lu, Y.3; Song, Q.1,2; Liu, W.1,2; Ma, D.1,2,3; Qiu, X.1,2
关键词CCDC134 secretory protein inhibit Elk1 MAPK pathway
刊名CELLULAR AND MOLECULAR LIFE SCIENCES
2008
DOI10.1007/s00018-007-7448-5
65期:2页:338-349
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]KINASE PATHWAYS ; CASCADES ; BETA
英文摘要

In this study, we report a novel gene, CCDC134 (coiled-coil domain containing 134), that encodes a secretory protein that can inhibit the MAPK pathway as a novel human MAPK-regulating protein. The CCDC134 mRNA contains 1280 nucleotides, encoding a protein of 229 amino acids. CCDC134 is a classical secretory protein. Expression profile analysis by Northern blot, RT-PCR, immunohistochemistry and Western blot reveals that CCDC134 is widely expressed in normal adult tissues, tumor tissues and cell lines. Functional investigation reveals that overexpression of CCDC134 and its purified protein significantly inhibit transcriptional activity of Elk1 and phosphorylation of Erk and JNK/SAPK but not p38 MAPK. Conversely, specific siRNA against CCDC134 activates Elk1 transcriptional activity and promotes Erk and JNK/SAPK phosphorylation. These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways.

语种英语
WOS记录号WOS:000252671200012
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64176
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学口腔医学院_牙体牙髓科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Human Dis Gen Ctr, Beijing 100083, Peoples R China
3.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
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GB/T 7714
Huang, J.,Shi, T.,Ma, T.,et al. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2008,65(2):338-349.
APA Huang, J..,Shi, T..,Ma, T..,Zhang, Y..,Ma, X..,...&Qiu, X..(2008).CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK.CELLULAR AND MOLECULAR LIFE SCIENCES,65(2),338-349.
MLA Huang, J.,et al."CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK".CELLULAR AND MOLECULAR LIFE SCIENCES 65.2(2008):338-349.
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