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学科主题: 基础医学
题名:
CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK
作者: Huang, J.1,2; Shi, T.1,2,3; Ma, T.1,2; Zhang, Y.1,2; Ma, X.1,2; Lu, Y.3; Song, Q.1,2; Liu, W.1,2; Ma, D.1,2,3; Qiu, X.1,2
关键词: CCDC134 ; secretory protein ; inhibit ; Elk1 ; MAPK pathway
刊名: CELLULAR AND MOLECULAR LIFE SCIENCES
发表日期: 2008
DOI: 10.1007/s00018-007-7448-5
卷: 65, 期:2, 页:338-349
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: KINASE PATHWAYS ; CASCADES ; BETA
英文摘要:

In this study, we report a novel gene, CCDC134 (coiled-coil domain containing 134), that encodes a secretory protein that can inhibit the MAPK pathway as a novel human MAPK-regulating protein. The CCDC134 mRNA contains 1280 nucleotides, encoding a protein of 229 amino acids. CCDC134 is a classical secretory protein. Expression profile analysis by Northern blot, RT-PCR, immunohistochemistry and Western blot reveals that CCDC134 is widely expressed in normal adult tissues, tumor tissues and cell lines. Functional investigation reveals that overexpression of CCDC134 and its purified protein significantly inhibit transcriptional activity of Elk1 and phosphorylation of Erk and JNK/SAPK but not p38 MAPK. Conversely, specific siRNA against CCDC134 activates Elk1 transcriptional activity and promotes Erk and JNK/SAPK phosphorylation. These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways.

语种: 英语
WOS记录号: WOS:000252671200012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64176
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Human Dis Gen Ctr, Beijing 100083, Peoples R China
3.Chinese Natl Human Genome Ctr, Beijing, Peoples R China

Recommended Citation:
Huang, J.,Shi, T.,Ma, T.,et al. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2008,65(2):338-349.
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