北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Pathologic Predictors of Renal Outcome and Therapeutic Efficacy in IgA Nephropathy: Validation of the Oxford Classification
作者: Shi, Su-Fang1,3,4; Wang, Su-Xia1,3,4; Jiang, Lei1,3,4; Lv, Ji-Gheng1,3,4; Liu, Li-Jun1,3,4; Chen, Yu-Qing1,3,4; Zhu, Sai-Nan2; Liu, Gang1,3,4; Zou, Wan-Zhong1,3,4; Zhang, Hong1,3,4; Wang, Hai-Yan1,3,4
刊名: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2011-09-01
DOI: 10.2215/CJN.11521210
卷: 6, 期:9, 页:2175-2184
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: IMMUNOGLOBULIN-A NEPHROPATHY ; CLINICOPATHOLOGICAL CORRELATION ; DISEASE ; GLOMERULONEPHRITIS ; PROLIFERATION ; PROTEINURIA ; PROGNOSIS ; SYSTEM
英文摘要:

Background and objectives The Oxford classification of IgA nephropathy (IgAN) may aid in predicting prognosis and providing therapeutic strategy but must be validated in different ancestry.

Design, setting, participants, & measurements A total of 410 patients with IgAN, enrolled from one of the largest renal centers in China, were evaluated for the predictive value of the Oxford classification to prognosis defined as end stage renal disease. A total of 294 of these patients were prospectively treated with renin-angiotensin system blockade and immunosuppressants sequentially and were evaluated separately to assess the predictive value to therapeutic efficacy (defined as time-averaged proteinuria <1 g/d). Three pathologists reviewed specimens independently according to the Oxford classification and were blinded to clinical data.

Results Segmental glomerulosclerosis and tubular atrophy and interstitial fibrosis were independent predictive factors of end stage renal disease. Patients who had >25% of glomeruli with endocapillary hypercellularity showed higher proteinuria, lower estimated GFR, and higher mean BP than patients with less endocapillary hypercellularity. Immunosuppressive therapy showed a protective effect to prognosis of endocapillary hypercellularity in patients with endoncapillary hypercellularity could benefit from immunosuppressive therapy. Mesangial hypercellularity and tubular atrophy and interstitial fibrosis were independent factors of inefficiency of renin-angiotensin system blockade alone. Crescents were not significant in predicting prognosis or in therapeutic efficacy.

Conclusions The Oxford classification may aid in predicting prognosis and providing a therapeutic strategy in Chinese patients with IgAN. Clin j Am Soc Nephrol 6: 2175-2184, 2011. doi:10.2215/CJN.11521210

语种: 英语
所属项目编号: 30825021 ; 200802052
项目资助者: National Science Fund Committee ; Foundation of Ministry of Health of China
WOS记录号: WOS:000294654200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64180
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Dept Med, Div Renal, Beijing 100034, Peoples R China
4.Peking Univ First Hosp, Dept Biostat, Beijing 100034, Peoples R China

Recommended Citation:
Shi, Su-Fang,Wang, Su-Xia,Jiang, Lei,et al. Pathologic Predictors of Renal Outcome and Therapeutic Efficacy in IgA Nephropathy: Validation of the Oxford Classification[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2011,6(9):2175-2184.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Su-Fang]'s Articles
[Wang, Su-Xia]'s Articles
[Jiang, Lei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Su-Fang]‘s Articles
[Wang, Su-Xia]‘s Articles
[Jiang, Lei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace