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学科主题: 临床医学
题名:
Relationship between cardio-ankle vascular index and N-terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects
作者: Wang, Hongyu; Liu, Jinbo; Zhao, Hongwei; Zhou, Yingyan; Zhao, Xujing; Song, Yuejie; Li, Lihong; Shi, Hongyan
关键词: Arterial stiffness ; Biomarkers
刊名: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
发表日期: 2014-09-01
DOI: 10.1016/j.jash.2014.05.009
卷: 8, 期:9, 页:637-643
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PULSE-WAVE VELOCITY ; ARTERIAL STIFFNESS ; CARDIOVASCULAR EVENTS ; COMMUNITY ; FAILURE ; CAVI ; ATHEROSCLEROSIS ; POPULATION ; BIOMARKERS ; MORTALITY
英文摘要:

Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong prognostic marker in advanced stage of coronary heart disease (CHD). In the present study, we investigated the relationship between CAVI and NT-proBNP in hypertension and CHD subjects. Five hundred one subjects (male/female, 209/292) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: healthy group (n = 186), hypertension group (n = 159), CHD group (n = 45), and hypertension with CHD group (n = 111). CAVI was measured using VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with CHD than in healthy and hypertension group, respectively (8.42 +/- 1.51 vs. 7.77 +/- 1.19; 8.42 +/- 1.51 vs. 7.92 +/- 1.11; both P <.05). NT-proBNP was significantly higher in hypertension subjects with CHD than in healthy, hypertension, and CHD group, respectively (422.48 +/- 761.60 vs. 174.29 +/- 415.48; 422.48 +/- 761.60 vs. 196.14 +/- 299.16; 422.48 +/- 761.60 vs. 209.66 +/- 242.66; all P <.05). And after log transformation of NT-proBNP, this phenomenon also exists (2.32 +/- 0.47 vs. 2.03 +/- 0.40; 2.32 +/- 0.47 vs. 2.09 +/- 0.44; 2.32 +/- 0.47 vs. 2.12 +/- 0.42; all P <.05). There was positive correlation between log NT-proBNP and CAVI in the entire study group, healthy group, and nonhealthy group (r = 0.235, P <.001; r = 0.184, P =.023; r = 0.237, P <.001; respectively). Multivariate analysis showed that NT-proBNP was an independent associating factor of CAVI in all subjects (beta=0.150, P =.021). Our present study showed that CAVI and NT-proBNP were significantly higher in hypertension subjects with CHD compared with healthy and hypertension groups. There was significant correlation between NT-proBNP and CAVI, which indicates the relationship between arterial stiffness and biomarkers in vascular-related diseases. Crown Copyright (C) 2014 Published by Elsevier Inc. on behalf of American Society of Hypertension. All rights reserved.

语种: 英语
所属项目编号: 2011-4026-02 ; 2010-Y002 ; 2014-Hospital-Clinical-02 ; 2012Y04 ; 2013 Keguan 20-1
项目资助者: Capital Health Research and Development of Special ; Peking University Shougang Hospital ; Shougang Keji Fund
WOS记录号: WOS:000342553100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64181
Appears in Collections:北京大学首钢医院_心血管内科_期刊论文

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作者单位: Peking Univ, Shougang Hosp, Dept Vasc Med, Beijing 100144, Peoples R China

Recommended Citation:
Wang, Hongyu,Liu, Jinbo,Zhao, Hongwei,et al. Relationship between cardio-ankle vascular index and N-terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects[J]. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION,2014,8(9):637-643.
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