北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Potential of 3,4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion-induced microvascular disturbance in rat mesentery
作者: Han, Jing-Yan1,2,4; Horie, Yoshinori2; Fan, Jing-Yu4; Sun, Kai4; Guo, Jun2,4; Miura, Soichiro3; Hibi, Toshifumi2
关键词: leukocyte adhesion ; mast cell degranulation ; oxidative stress ; Salvia miltiorrhiza
刊名: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
发表日期: 2009
DOI: 10.1152/ajpgi.90284.2008
卷: 296, 期:1, 页:G36-G44
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Physiology
研究领域[WOS]: Gastroenterology & Hepatology ; Physiology
关键词[WOS]: INDUCED LEUKOCYTE ADHESION ; SALVIA-MILTIORRHIZA ; MICROCIRCULATORY DISTURBANCE ; INJURY ; ISCHEMIA/REPERFUSION ; EXTRACT ; NEUTROPHILS ; ROSIGLITAZONE ; DYSFUNCTION ; PROTECTION
英文摘要:

Han J-Y, Horie Y, Fan J-Y, Sun K, Guo J, Miura S, Hibi T. Potential of 3,4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion- induced microvascular disturbance in rat mesentery. Am J Physiol Gastrointest Liver Physiol 296: G36-G44, 2009. First published November 13, 2008; doi:10.1152/ajpgi.90284.2008.-This study intended to examine the effect of 3,4- dihydroxy-phenyl lactic acid (DLA), a major ingredient of Salvia miltiorrhiza, on ischemia-reperfusion (I/R)-induced rat mesenteric microcirculatory injury. DLA (5 mg.kg(-1).h(-1)), superoxide dismutase (SOD, 12,000 U.kg(-1).h(-1)), or catalase (CAT, 20 mg/kg) was continuously infused either starting from 10 min before the ischemia or 10 min after the initiation of reperfusion. The venule diameter, number of adherent leukocytes, FITC-albumin leakage, dihydrorhodamine 123 fluorescence, and mast cell degranulation were determined using an intravital microscope. The production of hydrogen peroxide (H2O2) and the expression of adhesion molecules CD11b/CD18 in neutrophils were evaluated by in vitro experiments. The results showed that pretreatment with DLA significantly reduced peroxide production in and leukocyte adhesion to venular wall, albumin leakage, and mast cell degranulation induced by I/R. The DLA posttreatment exerted an ameliorating effect on I/R-induced disorders as well, characterized by inhibiting further increase in peroxide production in venular wall and albumin leakage and diminishing the number of leukocytes that had adhered to the venular wall. In vitro experiments revealed that treatment with DLA significantly attenuated TNF-alpha plus fMLP-evoked production of H2O2 and the H2O2-elicited expression of CD11b/CD18 on neutrophils. SOD and CAT manifested similarly but with the exception that either SOD or CAT were unable to retrieve the adherent leukocytes if administrated after initiation of reperfusion and to depress the H2O2-induced expression of CD11b/CD18 on neutrophils. It is concluded that DLA protects from and ameliorates the I/R-induced microcirculatory disturbance by interfering with both peroxide production and adhesion molecule expression.

语种: 英语
WOS记录号: WOS:000262063400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64185
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100083, Peoples R China
2.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
3.Natl Def Med Coll, Dept Internal Med, Saitama, Japan
4.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Han, Jing-Yan,Horie, Yoshinori,Fan, Jing-Yu,et al. Potential of 3,4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion-induced microvascular disturbance in rat mesentery[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,2009,296(1):G36-G44.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, Jing-Yan]'s Articles
[Horie, Yoshinori]'s Articles
[Fan, Jing-Yu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, Jing-Yan]‘s Articles
[Horie, Yoshinori]‘s Articles
[Fan, Jing-Yu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace