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Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009
Xiang, Yu-Tao1,2,3; Dickerson, Faith4; Kreyenbuhl, Julie3,5; Ungvari, Gabor S.6; Wang, Chuan-Yue2; Si, Tian-Mei7,8; Lee, Edwin H. M.1; Chiu, Helen F. K.1; Lai, Kelly Y. C.1; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Tan, Chay-Hoon13; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.15; Trivedi, Jitendra K.16; Chung, Eun-Kee17; Udomratn, Pichet18; Chee, Kok-Yoon19; Sartorius, Norman20; Shinfuku, Naotaka21
关键词schizophrenia prescription patterns anticholinergic older patients Asia
刊名INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
2013-03-01
DOI10.1002/gps.3827
28期:3页:305-311
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Gerontology ; Psychiatry
研究领域[WOS]Geriatrics & Gerontology ; Psychiatry
关键词[WOS]CHINESE PATIENTS ; TARDIVE-DYSKINESIA ; DRUG PRESCRIPTION ; EAST-ASIA ; ANTIPSYCHOTICS ; IMPAIRMENT ; WITHDRAWAL ; INPATIENTS ; EFFICACY ; MEMORY
英文摘要

Objective This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates. Method A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients′ socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure. Results The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications. Conclusions Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited. Copyright (c) 2012 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000314751800012
项目编号30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Science Foundation of China ; Beijing Nova Program of the Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health Research Grant in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64188
专题北京大学精神卫生研究所
作者单位1.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
2.Taipei City Hosp, Taipei, Taiwan
3.Chang Gung Univ, Sch Med, Gueishan, Taiwan
4.Natl Univ Singapore, Singapore 117548, Singapore
5.HITS, Kobe, Hyogo, Japan
6.Inst Mental Hlth, Singapore, Singapore
7.CSM Med Univ, Dept Psychiat, Lucknow, UP, India
8.Seoul Natl Hosp, Seoul, South Korea
9.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
10.Seinan Gakuin Univ, Sch Human Sci, Fukuoka, Japan
11.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
12.MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
13.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
14.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
15.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
17.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
18.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
19.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
20.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
21.Hosp Kuala Lumpur, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat andMental Hlth, Kuala Lumpur, Malaysia
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GB/T 7714
Xiang, Yu-Tao,Dickerson, Faith,Kreyenbuhl, Julie,et al. Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,2013,28(3):305-311.
APA Xiang, Yu-Tao.,Dickerson, Faith.,Kreyenbuhl, Julie.,Ungvari, Gabor S..,Wang, Chuan-Yue.,...&Shinfuku, Naotaka.(2013).Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009.INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,28(3),305-311.
MLA Xiang, Yu-Tao,et al."Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009".INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 28.3(2013):305-311.
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