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学科主题: 精神卫生
题名:
Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009
作者: Xiang, Yu-Tao1,2,3; Dickerson, Faith4; Kreyenbuhl, Julie3,5; Ungvari, Gabor S.6; Wang, Chuan-Yue2; Si, Tian-Mei7,8; Lee, Edwin H. M.1; Chiu, Helen F. K.1; Lai, Kelly Y. C.1; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Tan, Chay-Hoon13; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.15; Trivedi, Jitendra K.16; Chung, Eun-Kee17; Udomratn, Pichet18; Chee, Kok-Yoon19; Sartorius, Norman20; Shinfuku, Naotaka21
关键词: schizophrenia ; prescription patterns ; anticholinergic ; older patients ; Asia
刊名: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
发表日期: 2013-03-01
DOI: 10.1002/gps.3827
卷: 28, 期:3, 页:305-311
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology ; Gerontology ; Psychiatry
研究领域[WOS]: Geriatrics & Gerontology ; Psychiatry
关键词[WOS]: CHINESE PATIENTS ; TARDIVE-DYSKINESIA ; DRUG PRESCRIPTION ; EAST-ASIA ; ANTIPSYCHOTICS ; IMPAIRMENT ; WITHDRAWAL ; INPATIENTS ; EFFICACY ; MEMORY
英文摘要:

Objective This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates. Method A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients′ socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure. Results The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications. Conclusions Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited. Copyright (c) 2012 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Science Foundation of China ; Beijing Nova Program of the Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health Research Grant in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000314751800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64188
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
2.Taipei City Hosp, Taipei, Taiwan
3.Chang Gung Univ, Sch Med, Gueishan, Taiwan
4.Natl Univ Singapore, Singapore 117548, Singapore
5.HITS, Kobe, Hyogo, Japan
6.Inst Mental Hlth, Singapore, Singapore
7.CSM Med Univ, Dept Psychiat, Lucknow, UP, India
8.Seoul Natl Hosp, Seoul, South Korea
9.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
10.Seinan Gakuin Univ, Sch Human Sci, Fukuoka, Japan
11.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
12.MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
13.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
14.Sheppard Pratt, Stanley Res Program, Baltimore, MD USA
15.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
17.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
18.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
19.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
20.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
21.Hosp Kuala Lumpur, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat andMental Hlth, Kuala Lumpur, Malaysia

Recommended Citation:
Xiang, Yu-Tao,Dickerson, Faith,Kreyenbuhl, Julie,et al. Common use of anticholinergic medications in older patients with schizophrenia: findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,2013,28(3):305-311.
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