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学科主题: 临床医学
题名:
Evaluation of the Value of Fasting Plasma Glucose in the First Prenatal Visit to Diagnose Gestational Diabetes Mellitus in China
作者: Zhu, Wei-wei1; Yang, Hui-xia1; Wei, Yu-mei1; Yan, Jie1; Wang, Zi-lian2; Li, Xue-lan3; Wu, Hai-rong4; Li, Nan5; Zhang, Mei-hua6; Liu, Xing-hui7; Zhang, Hua8; Wang, Yun-hui9; Niu, Jian-min10; Gan, Yu-jie11; Zhong, Li-ruo12; Wang, Yun-feng13; Kapur, Anil14
刊名: DIABETES CARE
发表日期: 2013-03-01
DOI: 10.2337/dc12-1157
卷: 36, 期:3, 页:586-590
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: ADVERSE PREGNANCY OUTCOMES ; HYPERGLYCEMIA ; WOMEN
英文摘要:

OBJECTIVE-To evaluate the value of fasting plasma glucose (FPG) value in the first prenatal visit to diagnose gestational diabetes mellitus (GDM).

RESEARCH DESIGN AND METHODS-Medical records of 17,186 pregnant women attending prenatal clinics in 13 hospitals in China, including the Peking University First Hospital (PUFH), were examined. Patients with pre-GDM were excluded; data for FPG at the first prenatal visit and one-step GDM screening with 75-g oral glucose tolerance test (OGTT) performed between 24 and 28 weeks of gestation were collected and analyzed.

RESULTS-The median +/- SD FPG value was 4.58 +/- 0.437. FPG decreased with increasing gestational age. FPG level at the first prenatal visit was strongly correlated with GDM diagnosed at 24-28 gestational weeks (chi(2) = 959.3, P < 0.001). The incidences of GDM were 37.0, 52.7, and 66.2%, respectively, for women with FPG at the first prenatal visit between 5.10 and 5.59, 5.60 and 6.09, and 6.10-6.99 mmol/L. The data of PUFH were not statistically different from other hospitals.

CONCLUSIONS-Pregnant women (6.10 <= FPG < 7.00 mmol/L) should be considered and treated as GDM to improve outcomes; for women with FPG between 5.10 and 6.09 mmol/L, nutrition and exercise advice should be provided. An OGTT should be performed at 24-28 weeks to confirm or rule out GDM. Based on our data, we cannot support an FPG value >= 5.10 mmol/L at the first prenatal visit as the criterion for diagnosis of GDM. Diabetes Care 36:586-590, 2013

语种: 英语
项目资助者: World Diabetes Foundation
WOS记录号: WOS:000315928700026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64189
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.Aviat Gen Hosp, Beijing, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
4.Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Xian, Shanxi, Peoples R China
5.Tongzhou Maternal & Child Hlth Hosp Beijing, Beijing, Peoples R China
6.Maternal & Child Hlth Hosp Taiyuan, Taiyuan, Shanxi, Peoples R China
7.West China Second Univ Hosp, Chengdu, Sichuan, Peoples R China
8.Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China
10.Guangdong Women & Children Hosp, Guangzhou, Guangdong, Peoples R China
11.Boai Hosp Zhongshan, Guangzhou, Guangdong, Peoples R China
12.ShenZhen Peoples Hosp, Guangzhou, Guangdong, Peoples R China
13.Miyunxian Hosp, Beijing, Peoples R China
14.World Diabet Fdn, Gentofte, Denmark

Recommended Citation:
Zhu, Wei-wei,Yang, Hui-xia,Wei, Yu-mei,et al. Evaluation of the Value of Fasting Plasma Glucose in the First Prenatal Visit to Diagnose Gestational Diabetes Mellitus in China[J]. DIABETES CARE,2013,36(3):586-590.
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