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Cr(VI) exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins
Qu, Qingshan1; Li, Xiaomei1; An, Feiyun2; Jia, Guang3; Liu, Lanzeng4; Watanabe-Meserve, Hiroko1; Koenig, Karen1; Cohen, Beverly1; Costa, Max1; Roy, Nirmal1; Zhong, Mianhua1; Chen, Lung Chi1; Liu, Suhua4; Yan, Lei3
刊名BIOMARKERS
2008
DOI10.1080/13547500802099574
13期:5页:467-477
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]HEXAVALENT CHROMIUM COMPOUNDS ; OCCUPATIONAL EXPOSURE ; URINARY CHROMIUM ; BAND-3 MEMPHIS ; WORKERS ; BLOOD ; MECHANISMS ; CHROMATE ; CARCINOGENICITY ; LYMPHOCYTES
英文摘要

A total of 195 subjects, including 141 exposed workers and 54 farmers, were recruited in China to evaluate the usefulness of chromium (Cr) in erythrocytes as a biomarker of exposure to Cr(VI). The levels of Cr in red blood cells (RBC) were remarkably elevated even in a group of workers routinely exposed to Cr(VI) as low as 5-15 g m(-3) and showed a significant exposure-response trend over the exposure range from 0.002 to 1152 g m(-3) (p0.0001). Multiple linear regression analyses indicated that age and cigarette smoke were not associated with Cr in RBC. However, female subjects had lower Cr in RBC compared with their male counterparts for about the same exposure levels (p < 0.05). The genotypes of band III, which encodes for anion transport protein and may regulate CrO(4)(-2) across cell membranes, were also identified and included for analysis. The ratios of Cr in RBC to Cr(VI) exposure were higher in subjects with a wild genotype than in those who had heterozygous or homozygous variant alleles. However, the difference was not statistically significant probably due to the limited number of participating subjects. In addition, 15 of the 141 workers were selected for multiple exposure monitoring and blood sample collections to evaluate the inter- and intraindividual variations of Cr in RBC. Compared with the personal exposure levels, Cr in RBC had small intraindividual variations with a reliability coefficient of 0.88. The study suggests that Cr in RBC may serve as a sensitive and reliable biomarker for long-term exposure to Cr(VI).

语种英语
WOS记录号WOS:000257543500002
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64192
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
作者单位1.NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA
2.Cent S Univ, Sch Publ Hlth, Dept Toxicol, Changsha 410078, Hunan, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China
4.Jinan Municipal Ctr Dis Control & Prevent, Jinan 250013, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Qu, Qingshan,Li, Xiaomei,An, Feiyun,et al. Cr(VI) exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins[J]. BIOMARKERS,2008,13(5):467-477.
APA Qu, Qingshan.,Li, Xiaomei.,An, Feiyun.,Jia, Guang.,Liu, Lanzeng.,...&Yan, Lei.(2008).Cr(VI) exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins.BIOMARKERS,13(5),467-477.
MLA Qu, Qingshan,et al."Cr(VI) exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins".BIOMARKERS 13.5(2008):467-477.
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