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Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition
Zhang, Z. F.; Li, Q.; Liang, J.; Dai, X. Q.; Ding, Y.; Wang, J. B.; Li, Y.
关键词Epigallocatechin-3-O-gallate Dexamethasone Insulin resistance Rat L6 muscle cells
刊名PHYTOMEDICINE
2010
DOI10.1016/j.phymed.2009.09.007
17期:1页:14-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]GREEN TEA POLYPHENOL ; DIABETES-MELLITUS ; GLUCOSE-UPTAKE ; GALLATE ; INHIBITION ; MODULATION ; ACTIVATION ; EXPRESSION ; ADULTS ; GLUT4
英文摘要

The tea polyphenol epigallocatechin-3-O-gallate (EGCG) displays some antidiabetic effects; however the mechanisms are incompletely understood. In the present study, the investigation of the effects of EGCG on insulin resistance was performed in rat L6 cells treated with dexamethasone. We found that dexamethasone increased Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1) and reduced phosphorylation of AMPK and Akt. Furthermore, glucose uptake and glucose transporter (GLUT4) translocation were inhibited by dexamethasone. However, the treatment of EGCG improved insulin-stimulated glucose uptake by increasing GLUT4 translocation to plasma membrane. Furthermore, we also demonstrated these EGCG effects essentially depended on the AMPK and Akt activation. Together, our data suggested that EGCG inhibited dexamethasone-induced insulin resistance through AMPK and PI3K/Akt pathway. (C) 2009 Elsevier GmbH. All rights reserved.

语种英语
WOS记录号WOS:000274423300002
项目编号2006BAD27B01
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64194
专题北京大学公共卫生学院
北京大学临床肿瘤学院_药剂科
作者单位Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Z. F.,Li, Q.,Liang, J.,et al. Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition[J]. PHYTOMEDICINE,2010,17(1):14-18.
APA Zhang, Z. F..,Li, Q..,Liang, J..,Dai, X. Q..,Ding, Y..,...&Li, Y..(2010).Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition.PHYTOMEDICINE,17(1),14-18.
MLA Zhang, Z. F.,et al."Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition".PHYTOMEDICINE 17.1(2010):14-18.
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