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学科主题: 公共卫生
题名:
Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition
作者: Zhang, Z. F.; Li, Q.; Liang, J.; Dai, X. Q.; Ding, Y.; Wang, J. B.; Li, Y.
关键词: Epigallocatechin-3-O-gallate ; Dexamethasone ; Insulin resistance ; Rat L6 muscle cells
刊名: PHYTOMEDICINE
发表日期: 2010
DOI: 10.1016/j.phymed.2009.09.007
卷: 17, 期:1, 页:14-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: GREEN TEA POLYPHENOL ; DIABETES-MELLITUS ; GLUCOSE-UPTAKE ; GALLATE ; INHIBITION ; MODULATION ; ACTIVATION ; EXPRESSION ; ADULTS ; GLUT4
英文摘要:

The tea polyphenol epigallocatechin-3-O-gallate (EGCG) displays some antidiabetic effects; however the mechanisms are incompletely understood. In the present study, the investigation of the effects of EGCG on insulin resistance was performed in rat L6 cells treated with dexamethasone. We found that dexamethasone increased Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1) and reduced phosphorylation of AMPK and Akt. Furthermore, glucose uptake and glucose transporter (GLUT4) translocation were inhibited by dexamethasone. However, the treatment of EGCG improved insulin-stimulated glucose uptake by increasing GLUT4 translocation to plasma membrane. Furthermore, we also demonstrated these EGCG effects essentially depended on the AMPK and Akt activation. Together, our data suggested that EGCG inhibited dexamethasone-induced insulin resistance through AMPK and PI3K/Akt pathway. (C) 2009 Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 2006BAD27B01
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000274423300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64194
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Z. F.,Li, Q.,Liang, J.,et al. Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition[J]. PHYTOMEDICINE,2010,17(1):14-18.
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