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Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats
Lyu, Ying1; Feng, Xin1; Zhao, Pengling2; Wu, Zhenghao1; Xu, Hao1; Fang, Yuehui1; Hou, Yangfeng2; Denney, Liya3; Xu, Yajun1,4; Feng, Haotian2
关键词Fructus Ligustri Lucidi Calcium balance Bone mineral density Bone properties RANKL/OPG
刊名JOURNAL OF BONE AND MINERAL METABOLISM
2014-11-01
DOI10.1007/s00774-013-0536-8
32期:6页:616-626
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Medicine, Research & Experimental
研究领域[WOS]Endocrinology & Metabolism ; Research & Experimental Medicine
关键词[WOS]INTESTINAL CALCIUM-ABSORPTION ; OLEANOLIC ACID-DERIVATIVES ; VITAMIN-D ; OSTEOCLAST FORMATION ; OVARIECTOMIZED RATS ; IN-VITRO ; OSTEOPOROSIS ; OSTEOGENESIS ; EXPRESSION ; TURNOVER
英文摘要

Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL) ethanol extract on bone mineral density and its mechanical properties in growing female rats and to explore the underlying mechanisms. The rats were given different doses of FLL extract mixed with AIN-93G formula (0.40, 0.65 and 0.90 %), and a group given AIN-93G diet treatment only was used as control. The intervention lasted for 16 weeks until the animals were about 5 months old, the time when the animals almost reach their PBM. Our results showed that FLL treatment increased bone mineral density and improved bone mechanical properties in the growing female rats in a dose-dependent manner. In addition, FLL treatment significantly decreased the serum bone-resorbing marker, CTX-I, while significantly increasing serum 25(OH)D-3 and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio.

语种英语
WOS记录号WOS:000345285900002
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64197
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Nestle R&D Ctr China, Beijing 100095, Peoples R China
3.Nestle Res Ctr, CH-1000 Lausanne 26, Switzerland
4.Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lyu, Ying,Feng, Xin,Zhao, Pengling,et al. Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats[J]. JOURNAL OF BONE AND MINERAL METABOLISM,2014,32(6):616-626.
APA Lyu, Ying.,Feng, Xin.,Zhao, Pengling.,Wu, Zhenghao.,Xu, Hao.,...&Feng, Haotian.(2014).Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats.JOURNAL OF BONE AND MINERAL METABOLISM,32(6),616-626.
MLA Lyu, Ying,et al."Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats".JOURNAL OF BONE AND MINERAL METABOLISM 32.6(2014):616-626.
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