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学科主题: 公共卫生
题名:
Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats
作者: Lyu, Ying1; Feng, Xin1; Zhao, Pengling2; Wu, Zhenghao1; Xu, Hao1; Fang, Yuehui1; Hou, Yangfeng2; Denney, Liya3; Xu, Yajun1,4; Feng, Haotian2
关键词: Fructus Ligustri Lucidi ; Calcium balance ; Bone mineral density ; Bone properties ; RANKL/OPG
刊名: JOURNAL OF BONE AND MINERAL METABOLISM
发表日期: 2014-11-01
DOI: 10.1007/s00774-013-0536-8
卷: 32, 期:6, 页:616-626
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Medicine, Research & Experimental
研究领域[WOS]: Endocrinology & Metabolism ; Research & Experimental Medicine
关键词[WOS]: INTESTINAL CALCIUM-ABSORPTION ; OLEANOLIC ACID-DERIVATIVES ; VITAMIN-D ; OSTEOCLAST FORMATION ; OVARIECTOMIZED RATS ; IN-VITRO ; OSTEOPOROSIS ; OSTEOGENESIS ; EXPRESSION ; TURNOVER
英文摘要:

Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of osteoporosis later in life. The aims of this study were to investigate the effects of Fructus Ligustri Lucidi (FLL) ethanol extract on bone mineral density and its mechanical properties in growing female rats and to explore the underlying mechanisms. The rats were given different doses of FLL extract mixed with AIN-93G formula (0.40, 0.65 and 0.90 %), and a group given AIN-93G diet treatment only was used as control. The intervention lasted for 16 weeks until the animals were about 5 months old, the time when the animals almost reach their PBM. Our results showed that FLL treatment increased bone mineral density and improved bone mechanical properties in the growing female rats in a dose-dependent manner. In addition, FLL treatment significantly decreased the serum bone-resorbing marker, CTX-I, while significantly increasing serum 25(OH)D-3 and thereby increasing Ca absorption and Ca retention. Intriguingly, both in vivo and in vitro results demonstrated that FLL treatment could reduce the RANKL/OPG ratio. In conclusion, FLL ethanol extract exerted beneficial effects on peak bone mass acquisition and the improvement of bone mechanical properties by favoring Ca metabolism and decreasing the RANKL/OPG ratio.

语种: 英语
WOS记录号: WOS:000345285900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64197
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Nestle R&D Ctr China, Beijing 100095, Peoples R China
3.Nestle Res Ctr, CH-1000 Lausanne 26, Switzerland
4.Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China

Recommended Citation:
Lyu, Ying,Feng, Xin,Zhao, Pengling,et al. Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats[J]. JOURNAL OF BONE AND MINERAL METABOLISM,2014,32(6):616-626.
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