北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科  > 期刊论文
学科主题: 临床医学
题名:
Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis
作者: Ma, Yunfan1; Fan, Mengying1; Dai, Liang1; Kang, Xiaozheng1; Liu, Yiqiang2; Sun, Yu2; Xiong, Hongchao1; Liang, Zhen1; Yan, Wanpu1; Chen, Keneng1
关键词: Immunohistochemistry ; lung squamous cell carcinoma ; non-small cell lung cancer ; prognosis
刊名: THORACIC CANCER
发表日期: 2015-05-01
DOI: 10.1111/1759-7714.12181
卷: 6, 期:3, 页:288-295
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Respiratory System
研究领域[WOS]: Oncology ; Respiratory System
关键词[WOS]: IMMUNOHISTOCHEMICAL MARKERS ; CYTOKERATIN 5/6 ; CANCER ; ADENOCARCINOMA ; CLASSIFICATION ; DELTA-NP63 ; TTF-1 ; ASSOCIATION ; MUTATIONS ; SURVIVAL
英文摘要:

BackgroundNon-small cell lung cancer (NSCLC) accounts for 80% of lung cancers, and lung squamous cell carcinoma (SQCC) is one of the main types. Advances in the treatment of lung SQCC are lacking when compared to lung adenocarcinoma. The main treatment for early-stage SQCC is surgery. However, factors affecting the efficacy of surgical treatments for early-stage lung SQCC remain unclear. In this study, we examined the significance of commonly used lung SQCC diagnostic markers p63, p40, and cytokeratin (CK)5/6 in prognosis.

MethodsSeventy-six cases of early-stage lung SQCC (N-0) were obtained from our lung cancer database (January 2000 to December 2009). Tissue microarray and immunohistochemical (IHC) staining were used to detect the expression of p63, p40, and CK5/6. The effect of the expression level of each marker on patients′ survival was examined.

ResultsSensitivity and specificity of each marker for detecting lung SQCC was 87.0% and 81.0% for p63, 75.9% and 97.9% for p40, and 78.9% and 97.7% for CK5/6. Survival rates of patients with high expression levels of p63 or CK5/6 or both were higher than in patients with low expression levels (P < 0.05). Expression levels of p40 had no effect on survival (P > 0.05). Multivariate analysis showed that high levels of p63 expression p63+CK5/6 co-expression were independent prognostic factors for good survival.

ConclusionIHC staining detection of p63 and CK5/6 in specimens should be routinely performed in postoperative early-stage lung SQCC patients. Its significance lies not only in differential diagnosis, but also in determining prognosis.

语种: 英语
所属项目编号: 2009-2-17 ; 7102029 ; 2007-1023 ; 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003
项目资助者: Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China
WOS记录号: WOS:000353922500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64213
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Thorac Surg 1, Beijing 100036, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100036, Peoples R China

Recommended Citation:
Ma, Yunfan,Fan, Mengying,Dai, Liang,et al. Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis[J]. THORACIC CANCER,2015,6(3):288-295.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, Yunfan]'s Articles
[Fan, Mengying]'s Articles
[Dai, Liang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, Yunfan]‘s Articles
[Fan, Mengying]‘s Articles
[Dai, Liang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace