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IR@PKUHSC  > 北京大学临床肿瘤学院  > 病因研究室  > 期刊论文
学科主题: 临床医学
题名:
The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2
作者: Lu, Shaoli1; Yang, Yang1; Du, Yipeng1; Cao, Lin-lin1; Li, Meiting1; Shen, Changchun1; Hou, Tianyun1; Zhao, Ying1; Wang, Haiying1; Deng, Dajun2,3; Wang, Lina1; He, Qihua4; Zhu, Wei-Guo1,5
关键词: COX-2 ; c-Fos ; KDM2A ; histone methylation
刊名: ONCOTARGET
发表日期: 2015-10-27
卷: 6, 期:33, 页:34704-34717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: LUNG-CANCER ; DNA METHYLATION ; UP-REGULATION ; CELL-LINES ; CHROMATIN ; COX-2 ; GENE ; H3 ; APOPTOSIS ; PROMOTER
英文摘要:

Cyclooxygenase-2 (COX-2) is overexpressed in a variety of human epithelial cancers, including lung cancer, and is highly associated with a poor prognosis and a low survival rate. Understanding how COX-2 is regulated in response to carcinogens will offer insight into designing anti-cancer strategies and preventing cancer development. Here, we analyzed COX-2 expression in several human lung cancer cell lines and found that COX-2 expression was absent in the H719 and H460 cell lines by a DNA methylation-independent mechanism. The re-expression of COX-2 was observed after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment in both cell lines. Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment. In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines. Together, our data reveal a novel mechanism by which the carcinogen TPA activates COX-2 expression by regulating H3K36 dimethylation near the COX-2 promoter.

语种: 英语
所属项目编号: 2011CB504200 ; 2012CB517500 ; 31070691 ; 81321003 ; 91319302 ; 81071676 ; 81372165 ; 31261140372 ; 5142009
项目资助者: National Key Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000366107200064
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64214
Appears in Collections:北京大学临床肿瘤学院_病因研究室_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr,Dept Biochem & Mol Biol, State Key Lab Nat & Biomimet Drugs,Beijing Key La, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Sch Oncol, Dept Etiol, Beijing 100142, Peoples R China
3.Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China
5.Peking Univ Tsinghua Univ Joint Ctr Life Sci, Beijing 100751, Peoples R China

Recommended Citation:
Lu, Shaoli,Yang, Yang,Du, Yipeng,et al. The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2[J]. ONCOTARGET,2015,6(33):34704-34717.
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