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学科主题临床医学
The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2
Lu, Shaoli1; Yang, Yang1; Du, Yipeng1; Cao, Lin-lin1; Li, Meiting1; Shen, Changchun1; Hou, Tianyun1; Zhao, Ying1; Wang, Haiying1; Deng, Dajun2,3; Wang, Lina1; He, Qihua4; Zhu, Wei-Guo1,5
关键词COX-2 c-Fos KDM2A histone methylation
刊名ONCOTARGET
2015-10-27
6期:33页:34704-34717
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]LUNG-CANCER ; DNA METHYLATION ; UP-REGULATION ; CELL-LINES ; CHROMATIN ; COX-2 ; GENE ; H3 ; APOPTOSIS ; PROMOTER
英文摘要

Cyclooxygenase-2 (COX-2) is overexpressed in a variety of human epithelial cancers, including lung cancer, and is highly associated with a poor prognosis and a low survival rate. Understanding how COX-2 is regulated in response to carcinogens will offer insight into designing anti-cancer strategies and preventing cancer development. Here, we analyzed COX-2 expression in several human lung cancer cell lines and found that COX-2 expression was absent in the H719 and H460 cell lines by a DNA methylation-independent mechanism. The re-expression of COX-2 was observed after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment in both cell lines. Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment. In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines. Together, our data reveal a novel mechanism by which the carcinogen TPA activates COX-2 expression by regulating H3K36 dimethylation near the COX-2 promoter.

语种英语
WOS记录号WOS:000366107200064
项目编号2011CB504200 ; 2012CB517500 ; 31070691 ; 81321003 ; 91319302 ; 81071676 ; 81372165 ; 31261140372 ; 5142009
资助机构National Key Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64214
专题北京大学临床肿瘤学院_病因研究室
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学第三临床医学院_呼吸科
北京大学临床肿瘤学院_病因学研究室
作者单位1.Peking Univ, Hlth Sci Ctr,Dept Biochem & Mol Biol, State Key Lab Nat & Biomimet Drugs,Beijing Key La, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Sch Oncol, Dept Etiol, Beijing 100142, Peoples R China
3.Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Ctr Med & Hlth Anal, Beijing 100871, Peoples R China
5.Peking Univ Tsinghua Univ Joint Ctr Life Sci, Beijing 100751, Peoples R China
推荐引用方式
GB/T 7714
Lu, Shaoli,Yang, Yang,Du, Yipeng,et al. The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2[J]. ONCOTARGET,2015,6(33):34704-34717.
APA Lu, Shaoli.,Yang, Yang.,Du, Yipeng.,Cao, Lin-lin.,Li, Meiting.,...&Zhu, Wei-Guo.(2015).The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2.ONCOTARGET,6(33),34704-34717.
MLA Lu, Shaoli,et al."The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2".ONCOTARGET 6.33(2015):34704-34717.
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