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学科主题: 临床医学
题名:
Effect of relaxin on myocardial ischemia injury induced by isoproterenol
作者: Zhang, J; Qi, YF; Geng, B; Pan, CS; Zhao, J; Chen, L; Yang, J; Chang, JK; Tang, CS
关键词: relaxin ; cardiac ischemia ; isoproterenol
刊名: PEPTIDES
发表日期: 2005-09-01
DOI: 10.1016/j.peptides.2005.02.008
卷: 26, 期:9, 页:1632-1639
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: HEART-FAILURE ; RAT ; FIBROSIS ; GENE ; EXPRESSION ; PREGNANCY ; CORONARY ; COLLAGEN ; BINDING ; SYSTEM
英文摘要:

The omnipresent 6-kDa polypeptide relaxin (RLX) is emerging as a multifunctional endocrine and paracrine factor in a broad range of target tissues including cardiovascular tissues. To explore the pathophysiological roles of RLX in ischemic cardiovascular diseases, we studied the changes in RLX mRNA level in the myocardium and the effect of RLX supplements in rats with isoproterenol (ISO)-induced myocardial injury. In ISO-treated rats, RLX levels in myocardia and plasma increased 3.7- and 6.9-fold, respectively (P < 0.01), the mRNA level increased significantly in myocardia compared with controls. Co-administration of RLX (0.2 and 2.0 ug/kg/d) and ISO increased left-ventricular pressure development and decreased left ventricular end-diastolic pressure (LVDEP) (all P < 0.01). Malondialdehyde content in myocardia and lactate dehydrogenase and creatine phosphokinase activities in plasma in RLX-treated rats decreased markedly compared with that in ISO-treated alone rats (P < 0.01 or P < 0.05). In the high-dose RLX group, fibroblastic hyperplasia was relieved in myocardia, hydroxyproline level was lower, by 33% (P < 0.05), and endothelin content in plasma was lower, by 31 % (P < 0.01) than in the ISO-alone group. Compared with control group, any indexes in sham rats treated with high-dose RLX were unaltered (all P > 0.05). These results showed an up-regulation of myocardial RLX during ISO-induced myocardial ischemia injury and the protective effect of RLX on ISO-induced cardiac inhibition and fibrosis, which suggests that RLX could be an endogenous cardioprotective factor in ischemic heart diseases. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000232039600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64217
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ Mol Cardiol, Key Lab, Beijing 100083, Peoples R China
2.Phoenix Pharmaceut INC, Belmont, CA 94002 USA
3.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, J,Qi, YF,Geng, B,et al. Effect of relaxin on myocardial ischemia injury induced by isoproterenol[J]. PEPTIDES,2005,26(9):1632-1639.
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