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学科主题临床医学
PERITONEAL PROTEIN LEAKAGE, SYSTEMIC INFLAMMATION, AND PERITONITIS RISK IN PATIENTS ON PERITONEAL DIALYSIS
Dong, Jie1,2,3,4; Chen, Yuan1,2,3,4; Luo, Suping1,2,3,4; Xu, Rong1,2,3,4; Xu, Ying1,2,3,4
关键词Peritonitis protein leakage inflammation
刊名PERITONEAL DIALYSIS INTERNATIONAL
2013-05-01
DOI10.3747/pdi.2011.00326
33期:3页:273-279
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]TRANSPORT CHARACTERISTICS ; ENDOTHELIAL DYSFUNCTION ; EQUILIBRATION TEST ; SOLUTE TRANSPORT ; ALBUMIN ; MICROALBUMINURIA ; PREDICTOR ; INTERLEUKIN-6 ; DETERMINANTS ; INFECTIONS
英文摘要

Background: Whether peritoneal protein leakage predicts risk for peritonitis in patients on peritoneal dialysis (PD) is unknown. In this observational cohort study, we aimed to determine that association and, further, to explore if it might be explained by systemic inflammation.

Methods: We prospectively followed 305 incident PD patients to first-episode peritonitis, censoring, or the end of the study. Demographics, comorbidity score, biochemistry, and peritoneal protein clearance (PrC) were collected at baseline. The predictors of first-episode peritonitis were analyzed prospectively.

Results: During follow-up, 14 868 patient months and 251 episodes of peritonitis were observed. The baseline PrC was 73.2 mL/day (range: 53.2 - 102 mL/day). Patients with a high PrC were prone to be older and malnourished. They also had a higher comorbidity score and higher C-reactive protein values. In 132 first episodes of peritonitis, baseline PrC was shown to be a significant independent predictor after adjustment for age, sex, body mass index, diabetes, residual renal function, hemoglobin, and peritoneal transport rate. Systemic inflammatory markers such as serum albumin, C-reactive protein, and interleukin-6 could not explain the association of PrC and high risk for peritonitis.

Conclusions: Baseline peritoneal protein leakage was able to independently predict risk for peritonitis, which is not explained by systemic inflammation. The underlying mechanisms should be explored in future.

语种英语
WOS记录号WOS:000318850200008
项目编号Z111107058811110
资助机构Capital Characteristic Clinic Research Grant from the Beijing Science and Technology Committee ; New Century Excellent Talents from the Education Department, China ; Ketosteril Research Award from Fresenius Kabi Deutschland GmbH ; Baxter Clinical Research Award from Baxter Corporation, China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64223
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ First Hosp, Dept Med, Div Renal, Beijing, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ, Key Lab Renal Dis, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Dong, Jie,Chen, Yuan,Luo, Suping,et al. PERITONEAL PROTEIN LEAKAGE, SYSTEMIC INFLAMMATION, AND PERITONITIS RISK IN PATIENTS ON PERITONEAL DIALYSIS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2013,33(3):273-279.
APA Dong, Jie,Chen, Yuan,Luo, Suping,Xu, Rong,&Xu, Ying.(2013).PERITONEAL PROTEIN LEAKAGE, SYSTEMIC INFLAMMATION, AND PERITONITIS RISK IN PATIENTS ON PERITONEAL DIALYSIS.PERITONEAL DIALYSIS INTERNATIONAL,33(3),273-279.
MLA Dong, Jie,et al."PERITONEAL PROTEIN LEAKAGE, SYSTEMIC INFLAMMATION, AND PERITONITIS RISK IN PATIENTS ON PERITONEAL DIALYSIS".PERITONEAL DIALYSIS INTERNATIONAL 33.3(2013):273-279.
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