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学科主题: 临床医学
题名:
PERITONEAL PROTEIN LEAKAGE, SYSTEMIC INFLAMMATION, AND PERITONITIS RISK IN PATIENTS ON PERITONEAL DIALYSIS
作者: Dong, Jie1,2,3,4; Chen, Yuan1,2,3,4; Luo, Suping1,2,3,4; Xu, Rong1,2,3,4; Xu, Ying1,2,3,4
关键词: Peritonitis ; protein leakage ; inflammation
刊名: PERITONEAL DIALYSIS INTERNATIONAL
发表日期: 2013-05-01
DOI: 10.3747/pdi.2011.00326
卷: 33, 期:3, 页:273-279
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: TRANSPORT CHARACTERISTICS ; ENDOTHELIAL DYSFUNCTION ; EQUILIBRATION TEST ; SOLUTE TRANSPORT ; ALBUMIN ; MICROALBUMINURIA ; PREDICTOR ; INTERLEUKIN-6 ; DETERMINANTS ; INFECTIONS
英文摘要:

Background: Whether peritoneal protein leakage predicts risk for peritonitis in patients on peritoneal dialysis (PD) is unknown. In this observational cohort study, we aimed to determine that association and, further, to explore if it might be explained by systemic inflammation.

Methods: We prospectively followed 305 incident PD patients to first-episode peritonitis, censoring, or the end of the study. Demographics, comorbidity score, biochemistry, and peritoneal protein clearance (PrC) were collected at baseline. The predictors of first-episode peritonitis were analyzed prospectively.

Results: During follow-up, 14 868 patient months and 251 episodes of peritonitis were observed. The baseline PrC was 73.2 mL/day (range: 53.2 - 102 mL/day). Patients with a high PrC were prone to be older and malnourished. They also had a higher comorbidity score and higher C-reactive protein values. In 132 first episodes of peritonitis, baseline PrC was shown to be a significant independent predictor after adjustment for age, sex, body mass index, diabetes, residual renal function, hemoglobin, and peritoneal transport rate. Systemic inflammatory markers such as serum albumin, C-reactive protein, and interleukin-6 could not explain the association of PrC and high risk for peritonitis.

Conclusions: Baseline peritoneal protein leakage was able to independently predict risk for peritonitis, which is not explained by systemic inflammation. The underlying mechanisms should be explored in future.

语种: 英语
所属项目编号: Z111107058811110
项目资助者: Capital Characteristic Clinic Research Grant from the Beijing Science and Technology Committee ; New Century Excellent Talents from the Education Department, China ; Ketosteril Research Award from Fresenius Kabi Deutschland GmbH ; Baxter Clinical Research Award from Baxter Corporation, China
WOS记录号: WOS:000318850200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64223
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Dept Med, Div Renal, Beijing, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ, Key Lab Renal Dis, Beijing, Peoples R China

Recommended Citation:
Dong, Jie,Chen, Yuan,Luo, Suping,et al. PERITONEAL PROTEIN LEAKAGE, SYSTEMIC INFLAMMATION, AND PERITONITIS RISK IN PATIENTS ON PERITONEAL DIALYSIS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2013,33(3):273-279.
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