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Epigenetic regulation of Keap1-Nrf2 signaling
Guo, Yue1; Yu, Siwang2,3; Zhang, Chengyue1; Kong, Ah-Ng Tony1
关键词Nrf2 Keap1 Epigenetic DNA methylation Histone modification MicroRNAs
刊名FREE RADICAL BIOLOGY AND MEDICINE
2015-11-01
DOI10.1016/j.freeradbiomed.2015.06.013
88页:337-349
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
资助者National Natural Science Foundation of China ; National Cancer Institute (NCI) ; National Center for Curr Pharmacol Rep Complementary and Alternative Medicines (NCCAM) ; Office of Dietary Supplements (ODS) ; National Natural Science Foundation of China ; National Cancer Institute (NCI) ; National Center for Curr Pharmacol Rep Complementary and Alternative Medicines (NCCAM) ; Office of Dietary Supplements (ODS)
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
英文摘要

The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis serves as a "master regulator" in response to oxidative/electrophilic stresses and chemical insults through the coordinated induction of a wide array of cytoprotective genes. Therefore, activation of Nrf2 is considered to be an important approach for preventing chronic diseases triggered by stresses and toxins, including cancer. Despite extensive studies suggested that the Keap1-Nrf2 signaling pathway is subject to multiple layers of regulation at the transcriptional, translational, and post-translational levels, the potential epigenetic regulation of Nrf2 and Keapl has begun to be recognized only in recent years. Epigenetic modifications, heritable alterations in gene expression that occur without changes in the primary DNA sequence, have been reported to be profoundly involved in oxidative stress responses. In this review, we discuss the latest findings regarding the epigenetic regulation of Keapl-Nrf2 signaling by DNA methylation, histone modification, and microRNAs. The crosstalk among these epigenetic modifications in the regulation of Keapl-Nrf2 signaling pathways is also discussed. Studies of the epigenetic modification of Nrf2 and Keapl have not only enhanced our understanding of this complex cellular defense system but have also provided potential new therapeutic targets for the prevention of certain diseases.

语种英语
所属项目编号81272468 ; 81472657 ; R01-CA118947 ; R01-CA152826 ; R01AT007065
资助者National Natural Science Foundation of China ; National Cancer Institute (NCI) ; National Center for Curr Pharmacol Rep Complementary and Alternative Medicines (NCCAM) ; Office of Dietary Supplements (ODS) ; National Natural Science Foundation of China ; National Cancer Institute (NCI) ; National Center for Curr Pharmacol Rep Complementary and Alternative Medicines (NCCAM) ; Office of Dietary Supplements (ODS)
WOS记录号WOS:000363966300022
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64238
Collection北京大学药学院
作者单位1.Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA
2.State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Guo, Yue,Yu, Siwang,Zhang, Chengyue,et al. Epigenetic regulation of Keap1-Nrf2 signaling[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,88:337-349.
APA Guo, Yue,Yu, Siwang,Zhang, Chengyue,&Kong, Ah-Ng Tony.(2015).Epigenetic regulation of Keap1-Nrf2 signaling.FREE RADICAL BIOLOGY AND MEDICINE,88,337-349.
MLA Guo, Yue,et al."Epigenetic regulation of Keap1-Nrf2 signaling".FREE RADICAL BIOLOGY AND MEDICINE 88(2015):337-349.
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