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学科主题临床医学
Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo
Pan, Hong1,3; Hanada, Sayaka1; Zhao, Jun1,4; Mao, Li1,2; Ma, Mark Zhi-Qing1
刊名PLOS ONE
2012-11-09
DOI10.1371/journal.pone.0048799
7期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FACTOR RECEPTOR ; PAPP-A ; EPITHELIAL-CELLS ; OVARIAN-CANCER ; INSULIN ; BINDING ; RISK ; FIBROBLASTS ; INHIBITION ; EXPRESSION
英文摘要

Pregnancy-associated plasma protein-A (PAPPA) has been reported to regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. In this study we found that PAPPA is secreted from two out of seven lung cancer cell lines examined. None of immortalized normal bronchial epithelial cells (HBE) tested secrets PAPPA. There is no correlation between expression level and secretion of PAPPA in these cells. A cell line over-expressing PAPPA accompanied with secretion shows no notable changes in proliferation under cell culture conditions in vitro, but displays significantly augmentation of tumor growth in vivo in a xenograft model. In contrast, a cell line over-expressing PAPPA without secretion exhibits reduction of tumor growth both in vitro and in vivo. Down-regulation of PAPPA expression and secretion by RNAi knockdown decreases tumor growth after implanted in vivo. The tumor promoting activity of PAPPA appears to be mediated mainly through augmentation of the IGF signaling pathway as indicated by notable increases in downstream Akt kinase phosphorylation in tumor samples. Our results indicate that PAPPA secretion may play an important role in lung cancer growth and progression. Citation: Pan H, Hanada S, Zhao J, Mao L, Ma MZ-Q (2012) Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo. PLoS ONE 7(11): e48799. doi:10.1371/journal.pone.0048799

语种英语
WOS记录号WOS:000312272600021
项目编号R01 CA126818 ; R01 CA136635
资助机构National Institute of Health
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64240
专题北京大学临床肿瘤学院_胸部肿瘤内科
作者单位1.Univ Maryland, Sch Dent, Dept Oncol & Diagnost Sci, Baltimore, MD 21201 USA
2.Univ Maryland, Expt Therapeut Program, Greenbaum Canc Ctr, Baltimore, MD 21201 USA
3.Guangxi Univ, Affiliated Tumor Hosp, Dept Thorac Surg, Nanning, Guangxi Provinc, Peoples R China
4.Peking Univ, Dept Thorac Med Oncol, Beijing Canc Hosp, Sch Oncol,Beijing Canc Inst Canc Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Pan, Hong,Hanada, Sayaka,Zhao, Jun,et al. Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo[J]. PLOS ONE,2012,7(11).
APA Pan, Hong,Hanada, Sayaka,Zhao, Jun,Mao, Li,&Ma, Mark Zhi-Qing.(2012).Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo.PLOS ONE,7(11).
MLA Pan, Hong,et al."Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo".PLOS ONE 7.11(2012).
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