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学科主题: 临床医学
题名:
Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo
作者: Pan, Hong1,3; Hanada, Sayaka1; Zhao, Jun1,4; Mao, Li1,2; Ma, Mark Zhi-Qing1
刊名: PLOS ONE
发表日期: 2012-11-09
DOI: 10.1371/journal.pone.0048799
卷: 7, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FACTOR RECEPTOR ; PAPP-A ; EPITHELIAL-CELLS ; OVARIAN-CANCER ; INSULIN ; BINDING ; RISK ; FIBROBLASTS ; INHIBITION ; EXPRESSION
英文摘要:

Pregnancy-associated plasma protein-A (PAPPA) has been reported to regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. In this study we found that PAPPA is secreted from two out of seven lung cancer cell lines examined. None of immortalized normal bronchial epithelial cells (HBE) tested secrets PAPPA. There is no correlation between expression level and secretion of PAPPA in these cells. A cell line over-expressing PAPPA accompanied with secretion shows no notable changes in proliferation under cell culture conditions in vitro, but displays significantly augmentation of tumor growth in vivo in a xenograft model. In contrast, a cell line over-expressing PAPPA without secretion exhibits reduction of tumor growth both in vitro and in vivo. Down-regulation of PAPPA expression and secretion by RNAi knockdown decreases tumor growth after implanted in vivo. The tumor promoting activity of PAPPA appears to be mediated mainly through augmentation of the IGF signaling pathway as indicated by notable increases in downstream Akt kinase phosphorylation in tumor samples. Our results indicate that PAPPA secretion may play an important role in lung cancer growth and progression. Citation: Pan H, Hanada S, Zhao J, Mao L, Ma MZ-Q (2012) Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo. PLoS ONE 7(11): e48799. doi:10.1371/journal.pone.0048799

语种: 英语
所属项目编号: R01 CA126818 ; R01 CA136635
项目资助者: National Institute of Health
WOS记录号: WOS:000312272600021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64240
Appears in Collections:北京大学临床肿瘤学院_胸部肿瘤内科_期刊论文

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作者单位: 1.Univ Maryland, Sch Dent, Dept Oncol & Diagnost Sci, Baltimore, MD 21201 USA
2.Univ Maryland, Expt Therapeut Program, Greenbaum Canc Ctr, Baltimore, MD 21201 USA
3.Guangxi Univ, Affiliated Tumor Hosp, Dept Thorac Surg, Nanning, Guangxi Provinc, Peoples R China
4.Peking Univ, Dept Thorac Med Oncol, Beijing Canc Hosp, Sch Oncol,Beijing Canc Inst Canc Res, Beijing 100871, Peoples R China

Recommended Citation:
Pan, Hong,Hanada, Sayaka,Zhao, Jun,et al. Protein Secretion Is Required for Pregnancy-Associated Plasma Protein-A to Promote Lung Cancer Growth In Vivo[J]. PLOS ONE,2012,7(11).
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