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学科主题: 临床医学
题名:
Ultrastructural changes of podocyte foot processes during the remission phase of minimal change disease of human kidney
作者: Liu, Xiao-Jing1,2,3,4; Zhang, Yi-Miao1,2,3,4; Wang, Su-Xia5; Liu, Gang1,2,3,4
关键词: electron microscopy ; foot process ; minimal change disease ; podocyte ; proteinuria
刊名: NEPHROLOGY
发表日期: 2014-07-01
DOI: 10.1111/nep.12256
卷: 19, 期:7, 页:392-397
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ADULT NEPHROTIC SYNDROME ; GLOMERULAR LESIONS ; PROCESS EFFACEMENT ; PROTEINURIA
英文摘要:

Aim The current study was designed to observe the ultrastructural changes of podocyte foot processes during the remission phase and its relationship with the amount of the proteinuria in patients with minimal change disease (MCD). Methods Electron micrographs of glomerular capillaries were taken from 33 adult cases with MCD, including 12 cases with nephrotic syndrome, 15 cases in partial remission and six cases in complete remission. The foot processes were classified into three grades by the ratio of the height to basal width: 0.5-1, 1-2 and 2. The foot process width (FPW) and the number of foot processes in different grades per 10m of glomerular basement membrane (GBM) were measured. Normal renal tissues from 12 nephrectomies for renal carcinoma were selected as controls. Results There were statistical differences (P=0.001) in the mean FPW among the nephrotic group (1566.4 +/- 429.4nm), partial remission group (1007.8 +/- 234.9nm), complete remission group (949.8 +/- 168.2nm) and normal controls (471.9 +/- 51.8nm). For the height-to-width ratio 2, the number of foot process per 10m GBM was significantly greater in the normal group than that in the complete remission group (0.84 +/- 0.24 vs. 3.84 +/- 1.80, P=0.016). Taking all three groups of patients together, the mean FPW showed correlation with the level of proteinuria (r=0.506, P=0.003). Conclusion There may be no causal relationship between proteinuria and foot process effacement. In complete remission phase, both FPW and shape of foot process had not returned to normal while proteinuria disappeared.

语种: 英语
所属项目编号: 81370809
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000337611000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64245
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Electron Microscopy, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Xiao-Jing,Zhang, Yi-Miao,Wang, Su-Xia,et al. Ultrastructural changes of podocyte foot processes during the remission phase of minimal change disease of human kidney[J]. NEPHROLOGY,2014,19(7):392-397.
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