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学科主题临床医学
Ultrastructural changes of podocyte foot processes during the remission phase of minimal change disease of human kidney
Liu, Xiao-Jing1,2,3,4; Zhang, Yi-Miao1,2,3,4; Wang, Su-Xia5; Liu, Gang1,2,3,4
关键词electron microscopy foot process minimal change disease podocyte proteinuria
刊名NEPHROLOGY
2014-07-01
DOI10.1111/nep.12256
19期:7页:392-397
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ADULT NEPHROTIC SYNDROME ; GLOMERULAR LESIONS ; PROCESS EFFACEMENT ; PROTEINURIA
英文摘要

Aim The current study was designed to observe the ultrastructural changes of podocyte foot processes during the remission phase and its relationship with the amount of the proteinuria in patients with minimal change disease (MCD). Methods Electron micrographs of glomerular capillaries were taken from 33 adult cases with MCD, including 12 cases with nephrotic syndrome, 15 cases in partial remission and six cases in complete remission. The foot processes were classified into three grades by the ratio of the height to basal width: 0.5-1, 1-2 and 2. The foot process width (FPW) and the number of foot processes in different grades per 10m of glomerular basement membrane (GBM) were measured. Normal renal tissues from 12 nephrectomies for renal carcinoma were selected as controls. Results There were statistical differences (P=0.001) in the mean FPW among the nephrotic group (1566.4 +/- 429.4nm), partial remission group (1007.8 +/- 234.9nm), complete remission group (949.8 +/- 168.2nm) and normal controls (471.9 +/- 51.8nm). For the height-to-width ratio 2, the number of foot process per 10m GBM was significantly greater in the normal group than that in the complete remission group (0.84 +/- 0.24 vs. 3.84 +/- 1.80, P=0.016). Taking all three groups of patients together, the mean FPW showed correlation with the level of proteinuria (r=0.506, P=0.003). Conclusion There may be no causal relationship between proteinuria and foot process effacement. In complete remission phase, both FPW and shape of foot process had not returned to normal while proteinuria disappeared.

语种英语
WOS记录号WOS:000337611000005
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64245
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
作者单位1.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Electron Microscopy, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Xiao-Jing,Zhang, Yi-Miao,Wang, Su-Xia,et al. Ultrastructural changes of podocyte foot processes during the remission phase of minimal change disease of human kidney[J]. NEPHROLOGY,2014,19(7):392-397.
APA Liu, Xiao-Jing,Zhang, Yi-Miao,Wang, Su-Xia,&Liu, Gang.(2014).Ultrastructural changes of podocyte foot processes during the remission phase of minimal change disease of human kidney.NEPHROLOGY,19(7),392-397.
MLA Liu, Xiao-Jing,et al."Ultrastructural changes of podocyte foot processes during the remission phase of minimal change disease of human kidney".NEPHROLOGY 19.7(2014):392-397.
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