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学科主题临床医学
Family history of hypertension and arterial elasticity characteristics in healthy young people
Zhou, Lin; Chen, Yuanyuan; Sun, Ningling; Liu, Xirong
关键词arterial elasticity family history of hypertension large and small arterial compliance
刊名HYPERTENSION RESEARCH
2008-05-01
31期:5页:833-839
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]PULSE-WAVE ANALYSIS ; POSTMENOPAUSAL WOMEN ; CARDIOVASCULAR RISK ; BLOOD-PRESSURE ; INDEPENDENT PREDICTOR ; ESTROGEN-RECEPTOR ; AORTIC STIFFNESS ; VASCULAR-DISEASE ; MARKER ; ADULTS
英文摘要

Family history of hypertension is a primary predictor of high blood pressure (BP). This study attempted to determine whether there is a gradual increase in BP and an early change in arterial elasticity characteristics between young healthy individuals with or without a family history of hypertension and whether or not this increase is apparent in males as well as in females. A total of 270 normotensive healthy individuals (112 men and 158 women, aged 16 to 30 years) with or without a family history of hypertension, participated in conventional BP measurement and completed questionnaires covering basic information and a detailed family history of cardiovascular disease. Large arterial (capacitive) compliance (Cl) and small arterial (oscillatory or reflective) compliance (C-2) were derived from HDI/PulseWave CR-2000 (Hypertension Diagnostics, Minneapolis, USA). Based on family history information about parents and grandparents, three groups were formed: subjects with at least one hypertensive parent (group A), subjects with only hypertensive grandparents (group B), and subjects with normotensive parents and grandparents (group C). Men in group A had lower C-1 and C-2 along with higher systolic BP (SBP), diastolic BP (DBP), and heart rate than men in group C. Those in group B had intermediate C-1, C-2 and BP levels. C-1 had a linear relationship with SBP, DBP, and heart rate. In the logistic regression model of family history of hypertension, C-2 was lower in young normotensive males with parental hypertension (B = -0.315, exp B = 0.73, p = 0.03), independently of SBP, DBP, and heart rate. Among females, subjects with parental hypertension had higher systolic, mean arterial pressure, and pulse pressure (p < 0.05), and there were no significant differences in C-1 and C-2 between those with and those without parental hypertension. In conclusion, compared with normotensive offspring of normotensive parents, normotensive offspring of hypertensive parents had increased BP and impaired arterial properties, namely large and small arterial compliance as measured noninvasively by HDI. These differences were exhibited conspicuously in men but not in women. Alteration in arterial function in young non-hypertensive subjects may be a risk factor for hypertension and may contribute to the progression to hypertension later in life.

语种英语
WOS记录号WOS:000258391600002
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64248
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Cardiovascr Dept, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Lin,Chen, Yuanyuan,Sun, Ningling,et al. Family history of hypertension and arterial elasticity characteristics in healthy young people[J]. HYPERTENSION RESEARCH,2008,31(5):833-839.
APA Zhou, Lin,Chen, Yuanyuan,Sun, Ningling,&Liu, Xirong.(2008).Family history of hypertension and arterial elasticity characteristics in healthy young people.HYPERTENSION RESEARCH,31(5),833-839.
MLA Zhou, Lin,et al."Family history of hypertension and arterial elasticity characteristics in healthy young people".HYPERTENSION RESEARCH 31.5(2008):833-839.
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