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学科主题: 临床医学
题名:
A special healing pattern in stable metaphyseal fractures
作者: Chen, Wen Tao; Han, Da Cheng; Zhang, Pei Xun; Han, Na; Kou, Yu Hui; Yin, Xiao Feng; Jiang, Bao Guo
刊名: ACTA ORTHOPAEDICA
发表日期: 2015-04-01
DOI: 10.3109/17453674.2014.1003127
卷: 86, 期:2, 页:238-242
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Orthopedics
研究领域[WOS]: Orthopedics
关键词[WOS]: BONE HISTOMORPHOMETRY ; NOMENCLATURE ; SYMBOLS ; REPAIR ; UNITS ; RATS
英文摘要:

Background and purpose - Metaphyseal fractures heal in a rapid fashion that is different from the bone shaft healing process. Animal studies have focused on diaphyseal fractures. We investigated the metaphyseal fracture-healing process in rabbits.

Animals and methods - 60 rabbits (divided into 12 groups) underwent proximal tibial osteotomy, anatomical reduction, and fixation with screws. After surgery, the proximal tibiae were harvested at different time points for histology.

Results - No obvious osteonecrosis or bone resorption were found 2 weeks after surgery. From day 5 to week 5, woven bone or new trabeculae formed. From week 2, remodeling into lamellar bone started and reached a peak at week 6. These 3 stages overlapped. Histomorphometry showed that the structure changed as a unimodal curve.

Interpretation - The healing process of metaphyseal fractures appears to differ from the commonly studied healing process in diaphyseal fractures. It is rapid, and can be divided into 4 histological stages: cellular activation and differentiation, formation of woven bone, transformation of woven bone into lamellar bone, and further remodeling.

语种: 英语
所属项目编号: 2014CB542200 ; 31271284 ; 31171150 ; 81171146 ; 30971526 ; 31100860 ; 31040043 ; 31371210 ; 81372044 ; BMU 20110270 ; IRT1201
项目资助者: Chinese National Ministry of Science and Technology ; 973 Project Planning ; National Natural Science Fund ; Educational Ministry New Century Excellent Talents Support Project ; Ministry of Education Innovation Team
WOS记录号: WOS:000351740100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64251
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthopaed, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Wen Tao,Han, Da Cheng,Zhang, Pei Xun,et al. A special healing pattern in stable metaphyseal fractures[J]. ACTA ORTHOPAEDICA,2015,86(2):238-242.
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