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学科主题: 临床医学
题名:
Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study
作者: Xu, Yichen1; Chen, Yanzhi1; Li, Pingping1; Wang, Xin Shelley2
刊名: JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
发表日期: 2015-05-01
DOI: 10.1089/acm.2014.0211
卷: 21, 期:5, 页:281-287
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: TRADITIONAL CHINESE MEDICINE ; DOUBLE-BLIND ; CLINICAL-TRIALS ; SYMPTOM BURDEN ; CHEMOTHERAPY ; PLACEBO
英文摘要:

Objectives: This open-label, prospective, phase I/II trial was performed to establish the safety and efficacy of Traditional Chinese Medicine (TCM) herbal products for treating non-anemia-related fatigue in patients with cancer. Although this practice is widespread in China, it has not been confirmed in a prospective clinical study.

Design: Thirty-three patients who had completed cancer treatment, had stable disease and no anemia, and reported moderate to severe fatigue (rated >= 4 on a 0-10 scale) were enrolled in a TCM outpatient clinic. Patients took Ren Shen Yangrong Tang (RSYRT) decoction, a soup containing 12 TCM herbs, twice a day for 6 weeks. RSYRT aims to correct qi deficiency. Fatigue was assessed before and after RSYRT therapy, which all patients completed.

Results: No discomfort or toxicity was observed. Before the study, all patients had had fatigue for at least 4 months. Fatigue severity decreased significantly from before therapy to 6 weeks after therapy: from 7.06 to 3.30 on a 0-10 scale (p<0.001). Fatigue category (mild, moderate, severe) shifted significantly (p=0.024): Of 22 patients with severe fatigue (rated >= 7) before therapy, 11 had mild fatigue and 11 had moderate fatigue after TCM treatment. The time-to-fatigue-alleviation was 2-3 weeks.

Conclusion: RSYRT therapy was safe and was associated with fatigue improvement in nonanemic cancer survivors, consistent with historical TCM clinical practice experience. Because of a possible placebo effect in this open-label study, decoction RSYRT warrants further study in randomized clinical trials to confirm its effectiveness for managing moderate to severe fatigue.

语种: 英语
所属项目编号: NCI P01 CA124787 ; NCI P30 CA016672
项目资助者: Key Program Foundation of Beijing Administration of TCM ; National Cancer Institute (NCI) of the National Institutes of Health ; MD Anderson Cancer Center
WOS记录号: WOS:000354105100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64254
Appears in Collections:北京大学临床肿瘤学院_肿瘤中医_期刊论文

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作者单位: 1.Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Houston, TX 77030 USA
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Tradit Chinese Med, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Yichen,Chen, Yanzhi,Li, Pingping,et al. Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study[J]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,2015,21(5):281-287.
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