北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤中医  > 期刊论文
学科主题: 临床医学
题名:
Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study
作者: Xu, Yichen1; Chen, Yanzhi1; Li, Pingping1; Wang, Xin Shelley2
刊名: JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
发表日期: 2015-05-01
DOI: 10.1089/acm.2014.0211
卷: 21, 期:5, 页:281-287
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: TRADITIONAL CHINESE MEDICINE ; DOUBLE-BLIND ; CLINICAL-TRIALS ; SYMPTOM BURDEN ; CHEMOTHERAPY ; PLACEBO
英文摘要:

Objectives: This open-label, prospective, phase I/II trial was performed to establish the safety and efficacy of Traditional Chinese Medicine (TCM) herbal products for treating non-anemia-related fatigue in patients with cancer. Although this practice is widespread in China, it has not been confirmed in a prospective clinical study.

Design: Thirty-three patients who had completed cancer treatment, had stable disease and no anemia, and reported moderate to severe fatigue (rated >= 4 on a 0-10 scale) were enrolled in a TCM outpatient clinic. Patients took Ren Shen Yangrong Tang (RSYRT) decoction, a soup containing 12 TCM herbs, twice a day for 6 weeks. RSYRT aims to correct qi deficiency. Fatigue was assessed before and after RSYRT therapy, which all patients completed.

Results: No discomfort or toxicity was observed. Before the study, all patients had had fatigue for at least 4 months. Fatigue severity decreased significantly from before therapy to 6 weeks after therapy: from 7.06 to 3.30 on a 0-10 scale (p<0.001). Fatigue category (mild, moderate, severe) shifted significantly (p=0.024): Of 22 patients with severe fatigue (rated >= 7) before therapy, 11 had mild fatigue and 11 had moderate fatigue after TCM treatment. The time-to-fatigue-alleviation was 2-3 weeks.

Conclusion: RSYRT therapy was safe and was associated with fatigue improvement in nonanemic cancer survivors, consistent with historical TCM clinical practice experience. Because of a possible placebo effect in this open-label study, decoction RSYRT warrants further study in randomized clinical trials to confirm its effectiveness for managing moderate to severe fatigue.

语种: 英语
所属项目编号: NCI P01 CA124787 ; NCI P30 CA016672
项目资助者: Key Program Foundation of Beijing Administration of TCM ; National Cancer Institute (NCI) of the National Institutes of Health ; MD Anderson Cancer Center
WOS记录号: WOS:000354105100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64254
Appears in Collections:北京大学临床肿瘤学院_肿瘤中医_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Houston, TX 77030 USA
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Tradit Chinese Med, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Yichen,Chen, Yanzhi,Li, Pingping,et al. Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study[J]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,2015,21(5):281-287.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Yichen]'s Articles
[Chen, Yanzhi]'s Articles
[Li, Pingping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Yichen]‘s Articles
[Chen, Yanzhi]‘s Articles
[Li, Pingping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace