IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Pathology and pathogenesis of severe acute respiratory syndrome
Gu, Jiang; Korteweg, Christine
刊名AMERICAN JOURNAL OF PATHOLOGY
2007-04-01
DOI10.2353/ajpath.2007.061088
170期:4页:1136-1147
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]SYNDROME-ASSOCIATED CORONAVIRUS ; ANGIOTENSIN-CONVERTING ENZYME-2 ; SARS-ASSOCIATED CORONAVIRUS ; IN-SITU HYBRIDIZATION ; EPITHELIAL-CELLS ; DENDRITIC CELL ; DC-SIGN ; INFLAMMATORY CYTOKINES ; RETROSPECTIVE ANALYSIS ; PULMONARY PATHOLOGY
英文摘要

Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus; targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may he infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. in this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. it seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.

语种英语
WOS记录号WOS:000245233000002
Citation statistics
Cited Times:56[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64256
Collection北京大学基础医学院_病理学系
作者单位1.Peking Univ, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Infect Dis, Sch Basic Med Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Gu, Jiang,Korteweg, Christine. Pathology and pathogenesis of severe acute respiratory syndrome[J]. AMERICAN JOURNAL OF PATHOLOGY,2007,170(4):1136-1147.
APA Gu, Jiang,&Korteweg, Christine.(2007).Pathology and pathogenesis of severe acute respiratory syndrome.AMERICAN JOURNAL OF PATHOLOGY,170(4),1136-1147.
MLA Gu, Jiang,et al."Pathology and pathogenesis of severe acute respiratory syndrome".AMERICAN JOURNAL OF PATHOLOGY 170.4(2007):1136-1147.
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