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学科主题: 基础医学
题名:
Pathology and pathogenesis of severe acute respiratory syndrome
作者: Gu, Jiang; Korteweg, Christine
刊名: AMERICAN JOURNAL OF PATHOLOGY
发表日期: 2007-04-01
DOI: 10.2353/ajpath.2007.061088
卷: 170, 期:4, 页:1136-1147
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: SYNDROME-ASSOCIATED CORONAVIRUS ; ANGIOTENSIN-CONVERTING ENZYME-2 ; SARS-ASSOCIATED CORONAVIRUS ; IN-SITU HYBRIDIZATION ; EPITHELIAL-CELLS ; DENDRITIC CELL ; DC-SIGN ; INFLAMMATORY CYTOKINES ; RETROSPECTIVE ANALYSIS ; PULMONARY PATHOLOGY
英文摘要:

Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus; targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may he infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. in this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. it seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.

语种: 英语
WOS记录号: WOS:000245233000002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64256
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Infect Dis, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Gu, Jiang,Korteweg, Christine. Pathology and pathogenesis of severe acute respiratory syndrome[J]. AMERICAN JOURNAL OF PATHOLOGY,2007,170(4):1136-1147.
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