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Relationship between the contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of spontaneously hypertensive rats
Jiang, W; Jiang, HF; Pan, CS; Cai, DY; Qi, YF; Pang, YZ; Tang, CS
关键词spontaneously hypertensive rat adrenomedullin neutral endopeptidase
刊名HYPERTENSION RESEARCH
2004-02-01
27期:2页:109-117
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]VASOPEPTIDASE INHIBITORS ; HEART-FAILURE ; RENAL INJURY ; EXPRESSION ; CELLS ; PROADRENOMEDULLIN ; PRESSURE ; MICE ; GENE
英文摘要

Adrenomedullin (ADM) is a multifunctional peptide with important roles in the cardiovascular system, especially in the adjustment of cardiovascular and renal homeostasis. ADM is present in plasma, organs and tissues, and its activity increases during hypertension. It remains unknown whether the clearance of this peptide is altered during hypertension. Neutral endopeptidase (NEP) is the major enzyme in ADM′s degradation. We observed the activity and distribution of NEP and the expression of its mRNA in the plasma, cardiac ventricle, aorta, jejunum and kidney of spontaneously hypertensive rats (SHRs) in order to study the possible role of NEP in elevating tissue ADM concentrations during hypertension. ADM and NEP were diffuse in all tissues studied. The level of tissue ADM was generally higher in SHR tissues than in control tissues, except in the renal medulla, and its mRNA expression was higher in all tissues. Plasma NEP activity, general NEP activity and the expression of NEP mRNA in the left ventricle, aorta and jejunum in SHRs was lower than that of controls, and the level of ADM was inversely correlated with NEP activity. NEP activity and mRNA and protein expression in SHR kidneys were higher than in control kidneys; moreover, the ADM content was positively correlated with NEP activity in the renal cortex. NEP activity in the lung of SHRs did not differ from that of controls. Thus, in SHRs, the local concentration and action of ADM in the tissues may be differentially regulated by NEP.

语种英语
WOS记录号WOS:000189243300006
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64258
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Beijing 100871, Peoples R China
3.Reference Lab, Minist Hlth Cardiovasc Mol Biol & Regulatory Pept, Beijing, Peoples R China
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GB/T 7714
Jiang, W,Jiang, HF,Pan, CS,et al. Relationship between the contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of spontaneously hypertensive rats[J]. HYPERTENSION RESEARCH,2004,27(2):109-117.
APA Jiang, W.,Jiang, HF.,Pan, CS.,Cai, DY.,Qi, YF.,...&Tang, CS.(2004).Relationship between the contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of spontaneously hypertensive rats.HYPERTENSION RESEARCH,27(2),109-117.
MLA Jiang, W,et al."Relationship between the contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of spontaneously hypertensive rats".HYPERTENSION RESEARCH 27.2(2004):109-117.
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