|Clinical features of depression in Asia: Results of a large prospective, cross-sectional study|
|Srisurapanont, Manit1; Hong, Jin Pyo2; Si Tian-mei3; Hatim, Ahmad4; Liu, Chia-Yih5,6; Udomratn, Pichet7; Bae, Jae Nam8; Fang, Yiru9; Chua, Hong Choon10; Liu, Shen-Ing11; George, Tom12; Bautista, Dianne13,14; Chan, Edwin13,14; Rush, A. John13,14; MD RAN|
|关键词||Asian depression health status social support symptom|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|关键词[WOS]||DSM-IV ; MENTAL-HEALTH ; SCALE ; ANXIETY ; EXPERIENCES ; PREVALENCE ; INTERVIEW ; SEVERITY ; DISORDER ; QUALITY|
IntroductionThe objective of this study was to investigate the clinical features of depression in Asian patients.
MethodsIt was a cross-sectional, observational study of depression in China, Korea, Malaysia, Singapore, Taiwan, and Thailand. Participants were drug-free outpatients with depressed mood and/or anhedonia. Symptoms and clinical features were assessed using the Montgomery-Asberg Depression Rating Scale, Symptoms Checklist 90-Revised (SCL-90-R), and the Fatigue Severity Scale. Other measures included the Medical Outcome Survey 36-Item Short-Form Health Survey (SF-36), the Sheehan Disability Scale, and the Multidimensional Scale of Perceived Social Support (MSPSS).
ResultsA total of 547 outpatients with major depressive disorder were included in the analyses. Among the Montgomery-Asberg Depression Rating Scale symptoms, reported sadness and reduced sleep had the highest severity, with means (SDs) of 3.4 (1.2) and 3.4 (1.6), respectively. Apart from the SCL-90-R depression and anxiety domains, the SCL-90-R obsession-compulsion syndrome had the highest domain score, with a mean (SD) of 1.9 (0.9). Among eight domains, the mean (SD) SF-36 pain subscale score of 58.4 (27.7) was only second to that for the SF-36 physical function. In comparison to other disability domains, the Sheehan Disability Scale work/school had the highest subscale score, with a mean (SD) of 6.5 (2.9). The mean (SD) MSPSS family subscale score of 4.7 (1.7) was higher than the MSPSS friends and significant others subscale scores.
DiscussionThis study suggests that pain has a minimal impact on the quality of life in Asian patients with depression. Noteworthy issues in this population may include insomnia, obsessive-compulsive symptoms, working/school disability, and family support.
|资助机构||Lundbeck A/S ; Duke-National University of Singapore Office of Clinical Research ; AstraZeneca ; GlaxoSmithKline ; Pfizer ; Janssen-Cilag ; Johnson Johnson ; Lundbeck ; Sanofi-Aventis ; Servier|
|作者单位||1.Duke Natl Univ Singapore Grad Med Sch, Singapore, Singapore|
2.Chiang Mai Univ, Fac Med, Dept Psychiat, Muang, Thailand
3.Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, Seoul, South Korea
4.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
5.Univ Malaya, Fac Med, Dept Psychol Med, Kuala Lumpur, Malaysia
6.Chang Gung Med Ctr, Dept Psychiat, Tao Yuan, Tao Yuan County, Taiwan
7.Chang Gung Univ, Tao Yuan, Tao Yuan County, Taiwan
8.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
9.Woodbridge Hosp, Inst Mental Hlth, Singapore, Singapore
10.Mackay Mem Hosp, Fac Med, Dept Psychiat, Taipei, Taiwan
11.North West Specialist Ctr, Brisbane, Qld, Australia
12.Singapore Clin Res Inst, Singapore, Singapore
13.Inha Univ Hosp, Fac Med, Dept Psychiat, Inchon, South Korea
14.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai 200030, Peoples R China
|Srisurapanont, Manit,Hong, Jin Pyo,Si Tian-mei,et al. Clinical features of depression in Asia: Results of a large prospective, cross-sectional study[J]. ASIA-PACIFIC PSYCHIATRY,2013,5(4):259-267.|
|APA||Srisurapanont, Manit.,Hong, Jin Pyo.,Si Tian-mei.,Hatim, Ahmad.,Liu, Chia-Yih.,...&MD RAN.(2013).Clinical features of depression in Asia: Results of a large prospective, cross-sectional study.ASIA-PACIFIC PSYCHIATRY,5(4),259-267.|
|MLA||Srisurapanont, Manit,et al."Clinical features of depression in Asia: Results of a large prospective, cross-sectional study".ASIA-PACIFIC PSYCHIATRY 5.4(2013):259-267.|
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