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学科主题临床医学
Gabapentin markedly reduces acetic acid-induced visceral nociception
Feng, Y; Cui, ML; Willis, WD
刊名ANESTHESIOLOGY
2003-03-01
98期:3页:729-733
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology
研究领域[WOS]Anesthesiology
关键词[WOS]RANDOMIZED CONTROLLED TRIAL ; AMINO-ACID ; SPINAL-CORD ; ARTHRITIS MODEL ; NON-NMDA ; RAT ; NEUROPATHY ; NEURONS ; PAIN ; STIMULI
英文摘要

Background: Gabapentin has recently been used clinically as an antihyperalgesic agent to treat certain neuropathic pain states. The aim of this study is to test whether gabapentin is able to inhibit responses to peritoneal irritation-induced visceral pain and to examine the effect of gabapentin on spinal cord amino acid release.

Methods: The acetic acid-induced writhing assay was used in rats to determine the degree of antinociception. The rats received an intraperitoneal injection of acetic acid 40 min after intraperitoneal administration of vehicle or gabapentin (50, 100, or 200 mg/kg). Cerebrospinal fluid dialysate was collected by microdialysis from the spinal subarachnoid space in anesthetized rats. Acetic acid-induced release of amino acids into the dialysate, including glutamate, aspartate, serine, glutamine, and glycine, following intraperitoneal injection of acetic acid was evaluated by measurements of changes in the concentrations of these amino acids. The effects of pretreatment with saline or gabapentin (100 mg/kg intraperitoneal) on amino acid release were compared.

Results: Gabapentin reduced writhing responses in a dose-related fashion. Dialysate concentrations of glutamate, aspartate, and serine increased significantly following intraperitoneal injection of acetic acid, while glutamine and glycine concentrations were not increased significantly. When compared to saline-treated rats, animals pretreated with 100 mg/kg gabapentin showed suppression of the acetic acid-induced increases in glutamate, aspartate, and serine concentrations.

Conclusions: These data demonstrate that gabapentin effectively inhibits acetic acid-induced nociception, and the antinociceptive effect of gabapentin correlates with the suppression of noxious-evoked release of excitatory amino acids in the spinal cord.

语种英语
WOS记录号WOS:000181290800022
引用统计
被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64264
专题北京大学第二临床医学院_麻醉科
作者单位1.Univ Texas, Med Branch, Dept Anat & Neurosci, Galveston, TX 77555 USA
2.Allergan Pharmaceut Inc, Biol Sci, Irvine, CA 92715 USA
3.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100871, Peoples R China
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GB/T 7714
Feng, Y,Cui, ML,Willis, WD. Gabapentin markedly reduces acetic acid-induced visceral nociception[J]. ANESTHESIOLOGY,2003,98(3):729-733.
APA Feng, Y,Cui, ML,&Willis, WD.(2003).Gabapentin markedly reduces acetic acid-induced visceral nociception.ANESTHESIOLOGY,98(3),729-733.
MLA Feng, Y,et al."Gabapentin markedly reduces acetic acid-induced visceral nociception".ANESTHESIOLOGY 98.3(2003):729-733.
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