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学科主题医学信息学
Non-Cancer-Related Deaths From Suicide, Cardiovascular Disease, and Pneumonia in Patients With Oral Cavity and Oropharyngeal Squamous Carcinoma
Yu, Guo-Pei1,2,3,4; Mehta, Vikas1; Branovan, Daniel1,3; Huang, Qiang1,3; Schantz, Stimson P.1,3
刊名ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
2012
138期:1页:25-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Otorhinolaryngology ; Surgery
研究领域[WOS]Otorhinolaryngology ; Surgery
关键词[WOS]QUALITY-OF-LIFE ; NECK-CANCER ; HUMAN-PAPILLOMAVIRUS ; INCREASED RISK ; UNITED-STATES ; HEAD ; STROKE ; COHORT ; RADIOTHERAPY ; SURVIVAL
英文摘要

Objective: To study non-cancer-related mortality rates over time and examine the possible causes for several major deaths in patients with oral cavity and oropharyngeal (OC/OP) cancer.

Design: Retrospective cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) cancer registry data of the National Cancer Institute.

Main Outcome Measure: Cause-specific mortality rates during the first year after diagnosis of OC/OP cancer were calculated for 4 cohorts (1980-1984, 1990-1994, 2000-2003, and 2004-2007). The percentage changes over time were calculated. Standardized mortality ratios (SMRs) for suicide, cardiovascular disease, and pneumonia were calculated and compared with patient demographic and clinical characteristics.

Results: We analyzed data for 32 487 patients in 4 cohorts. From 1980-1984 to 2004-2007, mortality from suicide increased by 406.2% (P = .01), cardiovascular disease-related and pneumonia-related mortality decreased by 45.9% (P < .001) and 42.9% (P = .009), respectively, and rates of other non-cancer-related deaths did not change. Compared with the general population, patients diagnosed as having OC/OP cancer were at a significantly higher risk of mortality from suicide (SMR, 7.8; 95% CI, 4.6-12.4; P < .001), cardiovascular disease (SMR, 2.4; 95% CI, 2.1-2.7; P < .001), and pneumonia (SMR, 8.9; 95% CI, 6.8-11.5; P < .001) during the first year after cancer diagnosis. Risk factors for increased mortality included age of 55 to 64 years, marital status (including never married, divorced, or separated), advanced tumor stage (including regional and distant disease), treatment with radiotherapy alone, and pharyngeal tumor location.

Conclusions: Suicide rates have significantly increased in patients with OC/OP cancer since 1980 to 1984. Although cardiovascular disease- and pneumonia-related deaths have significantly decreased over time, they remain higher than the general US population. Increased knowledge of risk factors associated with non-cancer-related mortality in OC/OP cancer may lead to early intervention and enhanced overall survival.

语种英语
WOS记录号WOS:000299131300005
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64265
专题北京大学医学信息学中心
作者单位1.New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA
2.New York Eye & Ear Infirm, Biostat & Epidemiol Serv, New York, NY 10003 USA
3.New York Med Coll, Dept Otolaryngol, Valhalla, NY 10595 USA
4.Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yu, Guo-Pei,Mehta, Vikas,Branovan, Daniel,et al. Non-Cancer-Related Deaths From Suicide, Cardiovascular Disease, and Pneumonia in Patients With Oral Cavity and Oropharyngeal Squamous Carcinoma[J]. ARCHIVES OF OTOLARYNGOLOGY-HEAD &amp; NECK SURGERY,2012,138(1):25-32.
APA Yu, Guo-Pei,Mehta, Vikas,Branovan, Daniel,Huang, Qiang,&Schantz, Stimson P..(2012).Non-Cancer-Related Deaths From Suicide, Cardiovascular Disease, and Pneumonia in Patients With Oral Cavity and Oropharyngeal Squamous Carcinoma.ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY,138(1),25-32.
MLA Yu, Guo-Pei,et al."Non-Cancer-Related Deaths From Suicide, Cardiovascular Disease, and Pneumonia in Patients With Oral Cavity and Oropharyngeal Squamous Carcinoma".ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY 138.1(2012):25-32.
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