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学科主题: 临床医学
题名:
L-asparaginase-based regimen in the treatment of refractory midline nasal/nasal-type T/NK-cell lymphoma
作者: Yong, WB; Zhena, W; Zhang, YT; Zhu, J; Wei, Y; Zhu, DL; Li, JY
关键词: L-asparaginase ; treatment ; T/NK-cell lymphoma
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2003-08-01
卷: 78, 期:2, 页:163-167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: NON-HODGKINS-LYMPHOMA ; PROGNOSTIC FACTORS ; T-CELL ; CLASSIFICATION ; EXPRESSION ; RADIATION ; CHOP
英文摘要:

Nasal, nasal-type T-cell/natural killer cell (T/NK-cell) lymphoma is a rare disease, and its prognosis is poor. Between March 1992 and March 2002 we investigated a new L-asparaginase-based salvage regimen to treat the disease and improve response to treatment and 5-year overall survival rate. Eighteen patients with refractory midline nasal, nasal-type T/NK-cell lymphoma, who were resistant to a cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-like regimen, received an L-asparaginase-based salvage regimen (L-asparaginase, vincristine, and dexamethasone). Primary involved field radiation was given to the patients after chemotherapy. Ten (55.6%) of the patients achieved complete response (CR). Five patients (27.8%) achieved partial response (PR). The overall response rate (CR + PR) was 83.3%. The 5-year overall survival rate was 55.6%. Results of the preliminary clinical study indicated that the L-asparaginase-based salvage regimen significantly improved the response rate and 5-year survival rate. The findings suggested that the therapy is a promising new salvage regimen for treating refractory midline nasal, nasal-type T/NK-cell lymphoma. (C) 2003 The Japanese Society of Hematology.

语种: 英语
WOS记录号: WOS:000184978700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64267
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp, Sch Oncol, Dept Med Oncol, Beijing, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Sch Oncol, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Yong, WB,Zhena, W,Zhang, YT,et al. L-asparaginase-based regimen in the treatment of refractory midline nasal/nasal-type T/NK-cell lymphoma[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2003,78(2):163-167.
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