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学科主题: 临床医学
题名:
ACEI/ARB Underused in Patients with Type 2 Diabetes in Chinese Population (CCMR-3B Study)
作者: Xie, Qionghong1; Hao, Chuan-Ming1; Ji, Linong2; Hu, Dayi3; Zhu, Tongying1; Li, Xuehai4; Qin, Dandan4; Zhang, Danyi4
刊名: PLOS ONE
发表日期: 2015-02-12
DOI: 10.1371/journal.pone.0116970
卷: 10, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CONVERTING ENZYME-INHIBITORS ; CORONARY-HEART-DISEASE ; RENAL-DISEASE ; RECEPTOR BLOCKERS ; ACE-INHIBITORS ; NEPHROPATHY ; MELLITUS ; IRBESARTAN ; COMPLICATIONS ; EPIDEMIOLOGY
英文摘要:

Objective

In patients with diabetic kidney disease, it is well documented that RAS blockade is associated with an improved outcome. This observational, multicenter study examined the "real-world" use of ACEI/ARB in patients with type 2 diabetes (T2DM) in China.

Method

Data from the China Cardiometabolic Registries on blood pressure, blood lipid and blood glucose in Chinese T2DM patients (CCMR-3B) were used for the present study. Consecutive outpatients with T2DM for more than 6 months were recruited to this non-interventional, observational, cross-sectional study. Albuminuria was defined as urine albumin creatinine ratio (ACR) >= 30mg/g.

Results

A total of 25,454 outpatients with T2DM from 6 regions in China were enrolled, 47.0% were male, and 59.8% had hypertension. ACR was measured in 6,383 of these patients and 3,231 of them >= 30mg/L. Among patients with hypertension, 73.0% were on antihypertensives, and 39.7% used ACEI/ARB. Of the 2,157 patients with hypertension and albuminuria, only 48.3% used ACEI/ARB. Among the non-hypertensive patients with albuminuria, ACEI/ARB usage was <1%. Multivariate analysis revealed that comorbidities, region, hospital tier, physician specialty and patient′s educational level were associated with ACEI/ARB use.

Conclusion

In T2DM with hypertension and albuminuria in China, more than half of them were not treated with ACEI/ARB. This real world evidence suggests that the current treatment for patients with diabetes coexisting with hypertension and albuminuria in China is sub-optimal.

语种: 英语
所属项目编号: 201002010 ; 2011BAI10B05 ; NSFC: 81300569
项目资助者: Merck Sharp Dohme (China) ; Health Industry Special Scientific Research Projects, Ministry of Health ; National Science and Technology Ministry ; Natural Science Foundation of China
WOS记录号: WOS:000349914000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64270
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Fudan Univ, Div Nephrol, Huashan Hosp, Shanghai 200433, Peoples R China
2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China
4.VitalStrateg Res Inst, Berwyn, PA USA

Recommended Citation:
Xie, Qionghong,Hao, Chuan-Ming,Ji, Linong,et al. ACEI/ARB Underused in Patients with Type 2 Diabetes in Chinese Population (CCMR-3B Study)[J]. PLOS ONE,2015,10(2).
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