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学科主题: 药学
题名:
Safety Issues of Lanthanide-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry
作者: Wang Kui; Yang Xiaogai
关键词: lanthanides ; cellular inorganic chemistry ; similarity/dissimilarity principle ; proliferation ; cell signaling pathway ; safety
刊名: PROGRESS IN CHEMISTRY
发表日期: 2009-05-01
卷: 21, 期:5, 页:803-818
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: RARE-EARTH-ELEMENTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; METAL-ION SPECIATION ; GADOLINIUM CHLORIDE TOXICITY ; HUMAN ERYTHROCYTE-MEMBRANE ; MRI CONTRAST AGENTS ; HUMAN BLOOD-PLASMA ; MOTEXAFIN GADOLINIUM ; COMPUTER-SIMULATION ; MAGNETIC-RESONANCE
英文摘要:

The controversy about the safety issue concerning the agricultural application of lanthanides(Ln) has not yet been completely resolved. In recent years, the scientific basis of tire safety in relation to their uses as diagnostic agents and potential drugs has become the research focus. This review proposed several related critical problems in view of the cellular inorganic chemistry and discussed them from the following aspects. First, the role of the solid-phase formation and deposition in biological systems, as in the study of the biological effects of Ln, as well as elucidation of their performance on the clinical pathology, the formation, transformation, distribution and modulation of insoluble compounds have always been involved. Second, issues on the absorption, excretion and accumulation of Ln, especially on whether Ln cross the blood-tissue barriers, it is one of the foci of debate over their toxicity. Third, in the light of the similarity/dissimilarity principle, the common and specific characteristics of biological effects induced by Ln elements have been discussed. Fourth, the signaling pathways involved in the Ln-promoted cell proliferation and apoptosis, as well as the arising problems have been discussed. Based on the above discussions, the key issues faced by the cellular and biological studies on the metal ions or metal-based compounds have been proposed.

语种: 中文
WOS记录号: WOS:000266016000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64276
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Wang Kui,Yang Xiaogai. Safety Issues of Lanthanide-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry[J]. PROGRESS IN CHEMISTRY,2009,21(5):803-818.
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