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Safety Issues of Lanthanide-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry
Wang Kui; Yang Xiaogai
关键词lanthanides cellular inorganic chemistry similarity/dissimilarity principle proliferation cell signaling pathway safety
刊名PROGRESS IN CHEMISTRY
2009-05-01
21期:5页:803-818
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]RARE-EARTH-ELEMENTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; METAL-ION SPECIATION ; GADOLINIUM CHLORIDE TOXICITY ; HUMAN ERYTHROCYTE-MEMBRANE ; MRI CONTRAST AGENTS ; HUMAN BLOOD-PLASMA ; MOTEXAFIN GADOLINIUM ; COMPUTER-SIMULATION ; MAGNETIC-RESONANCE
英文摘要

The controversy about the safety issue concerning the agricultural application of lanthanides(Ln) has not yet been completely resolved. In recent years, the scientific basis of tire safety in relation to their uses as diagnostic agents and potential drugs has become the research focus. This review proposed several related critical problems in view of the cellular inorganic chemistry and discussed them from the following aspects. First, the role of the solid-phase formation and deposition in biological systems, as in the study of the biological effects of Ln, as well as elucidation of their performance on the clinical pathology, the formation, transformation, distribution and modulation of insoluble compounds have always been involved. Second, issues on the absorption, excretion and accumulation of Ln, especially on whether Ln cross the blood-tissue barriers, it is one of the foci of debate over their toxicity. Third, in the light of the similarity/dissimilarity principle, the common and specific characteristics of biological effects induced by Ln elements have been discussed. Fourth, the signaling pathways involved in the Ln-promoted cell proliferation and apoptosis, as well as the arising problems have been discussed. Based on the above discussions, the key issues faced by the cellular and biological studies on the metal ions or metal-based compounds have been proposed.

语种中文
WOS记录号WOS:000266016000002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64276
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
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GB/T 7714
Wang Kui,Yang Xiaogai. Safety Issues of Lanthanide-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry[J]. PROGRESS IN CHEMISTRY,2009,21(5):803-818.
APA Wang Kui,&Yang Xiaogai.(2009).Safety Issues of Lanthanide-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry.PROGRESS IN CHEMISTRY,21(5),803-818.
MLA Wang Kui,et al."Safety Issues of Lanthanide-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry".PROGRESS IN CHEMISTRY 21.5(2009):803-818.
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