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学科主题: 临床医学
题名:
In Vitro Activities of Nine Antifungal Drugs and Their Combinations against Phialophora verrucosa
作者: Li, Yali; Wan, Zhe; Li, Ruoyu1
刊名: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
发表日期: 2014-09-01
DOI: 10.1128/AAC.02875-14
卷: 58, 期:9, 页:5609-5612
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: AMPHOTERICIN-B ; FILAMENTOUS FUNGI ; CHROMOBLASTOMYCOSIS ; ITRACONAZOLE ; TERBINAFINE ; SUSCEPTIBILITY ; MICAFUNGIN ; PHEOHYPHOMYCOSIS ; CASPOFUNGIN ; SYNERGY
英文摘要:

The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (mu g/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combination of itraconazole plus caspofungin (with synergy against 100% of the 31 clinical strains), followed by amphotericin B plus flucytosine (45.2%) and itraconazole plus terbinafine or micafungin (25.8% or 12.9%, respectively).

语种: 英语
所属项目编号: Z121107009212026 ; 2013ZX10004612-002
项目资助者: Beijing Key Laboratory of Molecular Diagnosis of Dermatoses ; Ministry of Science and Technology of China
WOS记录号: WOS:000341262700076
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64279
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Beijing Key Lab Mol Diag Dermatoses, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol & Venereol, Beijing 100871, Peoples R China

Recommended Citation:
Li, Yali,Wan, Zhe,Li, Ruoyu. In Vitro Activities of Nine Antifungal Drugs and Their Combinations against Phialophora verrucosa[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2014,58(9):5609-5612.
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