IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
LAPTM4B Polymorphisms is Associated with Ovarian Cancer Susceptibility and Its Prognosis
Xu, Ye1; Liu, Yunduo1; Zhou, Rouli2; Meng, Fanling1; Gao, Ying1; Yang, Shanshan1; Li, Xueting1; Yang, Meng1; Lou, Ge1
关键词ovarian cancer LAPTM4B polymorphism susceptibility prognosis
刊名JAPANESE JOURNAL OF CLINICAL ONCOLOGY
2012-05-01
DOI10.1093/jjco/hys026
42期:5页:413-419
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; TETRATRANSMEMBRANE PROTEIN ; SACCHAROMYCES-CEREVISIAE ; MULTIDRUG-RESISTANCE ; CERVICAL-CARCINOMA ; MEMBRANE-PROTEIN ; OVEREXPRESSION ; EXPRESSION ; LYSOSOMES
英文摘要

Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is an important novel gene associated with the proliferation and differentiation of cells. Recent studies have shown that it was overexpressed in many cancer tissues. This study investigated the association between different LAPTM4B polymorphisms and the susceptibility and prognosis of ovarian cancer.

A casecontrol study was performed in 282 patients with ovarian cancer and 365 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction.

There was a significantly higher LAPTM4B2 allele frequency in ovarian cancer cases than controls (P 0.05). Using the LAPTM4B1/1 genotype as the reference, we found that the LAPTM4B1/2 and LAPTM4B2/2 genotypes were positively associated with ovarian cancer. Additionally, we found a negative correlation between the tumor grade and LAPTM4B allele genotype, which indicates strongly that LAPTM4B2 could affect the survival of patients.

These findings indicate that the LAPTM4B2 allele may be a risk factor for ovarian cancer and may play an important role in genetic susceptibility to ovarian cancer.

语种英语
WOS记录号WOS:000303331100007
项目编号2006RFLXS022
资助机构Harbin Special Funds for Technological Innovation, Harbin, Heilongjiang Province, China
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64282
专题北京大学基础医学院_细胞生物学系
作者单位1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gynecol, Harbin 150081, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Ye,Liu, Yunduo,Zhou, Rouli,et al. LAPTM4B Polymorphisms is Associated with Ovarian Cancer Susceptibility and Its Prognosis[J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY,2012,42(5):413-419.
APA Xu, Ye.,Liu, Yunduo.,Zhou, Rouli.,Meng, Fanling.,Gao, Ying.,...&Lou, Ge.(2012).LAPTM4B Polymorphisms is Associated with Ovarian Cancer Susceptibility and Its Prognosis.JAPANESE JOURNAL OF CLINICAL ONCOLOGY,42(5),413-419.
MLA Xu, Ye,et al."LAPTM4B Polymorphisms is Associated with Ovarian Cancer Susceptibility and Its Prognosis".JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42.5(2012):413-419.
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