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学科主题: 基础医学
题名:
LAPTM4B Polymorphisms is Associated with Ovarian Cancer Susceptibility and Its Prognosis
作者: Xu, Ye1; Liu, Yunduo1; Zhou, Rouli2; Meng, Fanling1; Gao, Ying1; Yang, Shanshan1; Li, Xueting1; Yang, Meng1; Lou, Ge1
关键词: ovarian cancer ; LAPTM4B ; polymorphism ; susceptibility ; prognosis
刊名: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
发表日期: 2012-05-01
DOI: 10.1093/jjco/hys026
卷: 42, 期:5, 页:413-419
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; TETRATRANSMEMBRANE PROTEIN ; SACCHAROMYCES-CEREVISIAE ; MULTIDRUG-RESISTANCE ; CERVICAL-CARCINOMA ; MEMBRANE-PROTEIN ; OVEREXPRESSION ; EXPRESSION ; LYSOSOMES
英文摘要:

Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is an important novel gene associated with the proliferation and differentiation of cells. Recent studies have shown that it was overexpressed in many cancer tissues. This study investigated the association between different LAPTM4B polymorphisms and the susceptibility and prognosis of ovarian cancer.

A casecontrol study was performed in 282 patients with ovarian cancer and 365 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction.

There was a significantly higher LAPTM4B2 allele frequency in ovarian cancer cases than controls (P 0.05). Using the LAPTM4B1/1 genotype as the reference, we found that the LAPTM4B1/2 and LAPTM4B2/2 genotypes were positively associated with ovarian cancer. Additionally, we found a negative correlation between the tumor grade and LAPTM4B allele genotype, which indicates strongly that LAPTM4B2 could affect the survival of patients.

These findings indicate that the LAPTM4B2 allele may be a risk factor for ovarian cancer and may play an important role in genetic susceptibility to ovarian cancer.

语种: 英语
所属项目编号: 2006RFLXS022
项目资助者: Harbin Special Funds for Technological Innovation, Harbin, Heilongjiang Province, China
WOS记录号: WOS:000303331100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64282
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gynecol, Harbin 150081, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Ye,Liu, Yunduo,Zhou, Rouli,et al. LAPTM4B Polymorphisms is Associated with Ovarian Cancer Susceptibility and Its Prognosis[J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY,2012,42(5):413-419.
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