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学科主题: 临床医学
题名:
Expression of 1A6 gene and its correlation with intestinal gastric carcinoma
作者: Liu, YQ; Zhao, H; Ning, T; Ke, Y; Li, JY
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2003-02-01
卷: 9, 期:2, 页:238-241
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CANCER ; METAPLASIA ; CARCINOGENESIS ; CLASSIFICATION ; PROTEINS
英文摘要:

AIM: To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma.

METHODS: One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method.

RESULTS: The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2 %, 16.7 %, 7.1 %, 22.6 %, 47.8 %, 46.9 % and 60.8 %, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P<0.01), the difference between type III and Dys, IGC being not significant.

CONCLUSION: As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.

语种: 英语
WOS记录号: WOS:000180736500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64284
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100036, Peoples R China
2.Peking Univ, Genet Lab, Sch Oncol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, YQ,Zhao, H,Ning, T,et al. Expression of 1A6 gene and its correlation with intestinal gastric carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(2):238-241.
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