IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Vesicular Glutamate Transporter-3 Contributes to Visceral Hyperalgesia Induced by Trichinella spiralis Infection in Rats
Yang, Chang-qing1; Wei, Yan-yu1; Leng, Yu-xin1; Zhong, Chan-juan1; Zhang, Yong-shen1; Wan, You2; Duan, Li-ping1
关键词Vesicular glutamate transporter-3 Visceral hyperalgesia Trichinella spiralis Stress Rat
刊名DIGESTIVE DISEASES AND SCIENCES
2012-04-01
DOI10.1007/s10620-011-1970-x
57期:4页:865-872
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]IRRITABLE-BOWEL-SYNDROME ; PAIN ; HYPERSENSITIVITY ; NEURONS
英文摘要

According to a recent study, vesicular glutamate transporter-3 (VGLUT3) contributes to injury-induced mechanical hyperalgesia in mice.

The aims of the study were to investigate whether VGLUT3 is involved in visceral pain, and whether transient intestinal infection or acute cold restraint stress (ACRS) affects VGLUT3 expression levels in rats.

Changes in VGLUT3 and c-Fos proteins were evaluated in rats which received noxious colorectal distension (CRD) stimulation. Transient intestinal infection was effected by oral administration of Trichinella spiralis (T. spiralis) larvae in Brown Norway rats. On the 100th day post-infection (PI), half of the PI-rats and non infected controls were subjected to an ACRS procedure. The visceromotor response to CRD was measured using the abdominal withdrawal reflex (AWR) score. Immunofluorescence and western blot analysis were used to estimate the expression of VGLUT3 in both peripheral and central neurons.

Noxious stimulation induced a significant increase in the expression of VGLUT3 in the L6S1 spinal dorsal horn. Compared with the control group, the pain threshold was significantly decreased in the ACRS, PI, and PI + ACRS groups. VGLUT3 expression in the L6S1 dorsal root ganglion (DRG) and spinal neurons were significantly increased in PI and PI + ACRS groups as compared with the control group.

VGLUT3 is involved in conduction of visceral pain sensation and in visceral hyperalgesia induced by Trichinella spiralis infection in rats.

语种英语
WOS记录号WOS:000301835600008
项目编号30940033
资助机构National Natural Science Foundation of China ; Doctoral Program of Higher Education of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64294
专题北京大学第三临床医学院_消化科
北京大学医学部管理机构_科学研究处
北京大学第三临床医学院_危重医学科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Chang-qing,Wei, Yan-yu,Leng, Yu-xin,et al. Vesicular Glutamate Transporter-3 Contributes to Visceral Hyperalgesia Induced by Trichinella spiralis Infection in Rats[J]. DIGESTIVE DISEASES AND SCIENCES,2012,57(4):865-872.
APA Yang, Chang-qing.,Wei, Yan-yu.,Leng, Yu-xin.,Zhong, Chan-juan.,Zhang, Yong-shen.,...&Duan, Li-ping.(2012).Vesicular Glutamate Transporter-3 Contributes to Visceral Hyperalgesia Induced by Trichinella spiralis Infection in Rats.DIGESTIVE DISEASES AND SCIENCES,57(4),865-872.
MLA Yang, Chang-qing,et al."Vesicular Glutamate Transporter-3 Contributes to Visceral Hyperalgesia Induced by Trichinella spiralis Infection in Rats".DIGESTIVE DISEASES AND SCIENCES 57.4(2012):865-872.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Chang-qing]的文章
[Wei, Yan-yu]的文章
[Leng, Yu-xin]的文章
百度学术
百度学术中相似的文章
[Yang, Chang-qing]的文章
[Wei, Yan-yu]的文章
[Leng, Yu-xin]的文章
必应学术
必应学术中相似的文章
[Yang, Chang-qing]的文章
[Wei, Yan-yu]的文章
[Leng, Yu-xin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。