IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Intracoronary infusion of Wharton′s jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial
Gao, Lian R.1; Chen, Yu1; Zhang, Ning K.1; Yang, Xi L.2; Liu, Hui L.3; Wang, Zhi G.1; Yan, Xiao Y.5; Wang, Yu7; Zhu, Zhi M.1; Li, Tian C.1; Wang, Li H.1; Chen, Hai Y.1; Chen, Yun D.6; Huang, Chao L.8; Qu, Peng9; Yao, Chen5; Wang, Bin10; Chen, Guang H.6; Wang, Zhong M.11; Xu, Zhao Y.2; Bai, Jing7; Lu, Di13; Shen, Yan H.15; Guo, Feng14; Liu, Mu Y.4; Yang, Yong3; Ding, Yan C.9; Yang, Ye1; Tian, Hai T.1; Ding, Qing A.1; Li, Li N.8; Yang, Xin C.12; Hu, Xiang4
关键词Myocardial infarction Mesenchymal stem cells Wharton&prime s jelly of umbilical cord
刊名BMC MEDICINE
2015-07-10
DOI10.1186/s12916-015-0399-z
13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Advanced Technology Development Project of China (863 Project) ; National Advanced Technology Development Project of China (863 Project)
研究领域[WOS]General & Internal Medicine
关键词[WOS]HUMAN UMBILICAL-CORD ; HEART-FAILURE ; TRANSPLANTATION ; REGENERATION ; POPULATION ; EFFICACY ; OUTCOMES ; DISEASE ; BIOLOGY ; STROMA
英文摘要

Background: The use of adult stem cells is limited by the quality and quantity of host stem cells. It has been demonstrated that Wharton′s jelly-derived mesenchymal stem cells (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues and significantly improve heart function. In this randomized, controlled trial, our aim was to assess the safety and efficacy of intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI).

Methods: In a multicenter trial, 116 patients with acute ST-elevation MI were randomly assigned to receive an intracoronary infusion of WJMSCs or placebo into the infarct artery at five to seven days after successful reperfusion therapy. The primary endpoint of safety: the incidence of adverse events (AEs) within 18 months, was monitored and quantified. The endpoint of efficacy: the absolute changes in myocardial viability and perfusion of the infarcted region from baseline to four months, global left ventricular ejection fraction (LVEF) from baseline to 18 months were measured using F-18-fluorodeoxyglucose positron emission computed tomography (F-18-FDG-PET) and 99mTc-sestamibi single-photon emission computed tomography (99mTc-SPECT), and two-dimensional echocardiography, respectively.

Results: During 18 months follow-up, AEs rates and laboratory tests including tumor, immune, and hematologic indexes were not different between the two groups. The absolute increase in the myocardial viability (PET) and perfusion within the infarcted territory (SPECT) was significantly greater in the WJMSC group [6.9 +/- 0.6 % (95 % CI, 5.7 to 8.2)] and [7.1 +/- 0.8 % (95 % CI, 5.4 to 8.8) than in the placebo group [3.3 +/- 0.7 % (95 % CI, 1.8 to 4.7), P < 0.0001] and 3.9 +/- 0.6(95 % CI, 2.8 to 5.0), P = 0.002] at four months. The absolute increase in the LVEF at 18 months in the WJMSC group was significantly greater than that in the placebo group [7.8 +/- 0.9 (6.0 to approximately 9.7) vs. 2.8 +/- 1.2 (0.4 to approximately 5.1), P = 0.001]. Concomitantly, the absolute decreases in LV end-systolic volumes and end-diastolic volumes at 18 months in the WJMSC group were significantly greater than those in the placebo group (P = 0.0004, P = 0.004, respectively).

Conclusions: Intracoronary infusion of WJMSCs is safe and effective in patients with AMI, providing clinically relevant therapy within a favorable time window. This study encourages additional clinical trials to determine whether WJMSCs may serve as a novel alternative to BMSCs for cardiac stem cell-based therapy.

语种英语
所属项目编号2006AA02Z469 ; 2011AA020102 ; 2013AA020101
资助者National Advanced Technology Development Project of China (863 Project) ; National Advanced Technology Development Project of China (863 Project)
WOS记录号WOS:000357710700001
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64309
Collection北京大学第一临床医学院
作者单位1.Shenzhen Beike Cell Engn Res Inst, Shenzhen, Guangdong, Peoples R China
2.Chinese PLA, Gen Hosp, Dept Age Cardiol, Beijing, Peoples R China
3.Beijing Huaxin Hosp, Dept Cardiol, Beijing, Peoples R China
4.Aerosp Corp, Cent Hosp, Dept Cardiol, Beijing, Peoples R China
5.Navy Gen Hosp, Dept Nucl Med, Beijing, Peoples R China
6.Navy Gen Hosp, Dept Ultrason Diag, Beijing, Peoples R China
7.Navy Gen Hosp, Ctr Cardiol, Beijing, Peoples R China
8.Armed Police Forces, Gen Hosp, Dept Cardiol, Beijing, Peoples R China
9.First Peoples Hosp Foshan, Dept Cardiol, Foshan, Guangdong, Peoples R China
10.Peking Univ, Hosp 1, Clin Res Inst, Dept Biostat, Beijing 100871, Peoples R China
11.Chinese Peoples Liberat Army, Gen Hosp, Dept Cardiol, Beijing, Peoples R China
12.Dalian Med Univ, Affiliated Hosp 2, Dept Cardiol, Dalian, Liaoning Provin, Peoples R China
13.Huabei Oilfield, Gen Hosp, Dept Cardiol, Renqiu, Huabei Province, Peoples R China
14.Capital Med Univ, Beijing Chaoyang Hosp, Dept Cardiol, Beijing, Peoples R China
15.Natl Petr Corp, Cent Hosp, Dept Cardiol, Langfang, Huabei Province, Peoples R China
Recommended Citation
GB/T 7714
Gao, Lian R.,Chen, Yu,Zhang, Ning K.,et al. Intracoronary infusion of Wharton&prime;s jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial[J]. BMC MEDICINE,2015,13.
APA Gao, Lian R..,Chen, Yu.,Zhang, Ning K..,Yang, Xi L..,Liu, Hui L..,...&Hu, Xiang.(2015).Intracoronary infusion of Wharton′s jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial.BMC MEDICINE,13.
MLA Gao, Lian R.,et al."Intracoronary infusion of Wharton′s jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial".BMC MEDICINE 13(2015).
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