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学科主题: 临床医学
题名:
Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation
作者: Tapmeier, T. T.1,2,3; Brown, K. L.1,2,3; Tang, Z.1,2,3,4; Sacks, S. H.1,2,3; Sheerin, N. S.5; Wong, W.1,2,3
关键词: renal fibrosis ; UUO ; reimplantation ; inflammation
刊名: KIDNEY INTERNATIONAL
发表日期: 2008-04-01
DOI: 10.1038/sj.ki.5002797
卷: 73, 期:7, 页:885-889
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: MICE ; FIBROSIS ; RELIEF ; RATS
英文摘要:

Experimental unilateral ureteral obstruction (UUO) is widely used to study renal fibrosis; however, renal injury can only be scored semiobjectively by histology. We sought to improve the UUO model by reimplanting the obstructed ureter followed by removal of the contralateral kidney, thus allowing longitudinal measurements of renal function. Mice underwent UUO for different lengths of time before ureteral reimplantation and contralateral nephrectomy. Measurement of blood urea nitrogen (BUN) allows objective evaluation of residual renal function. Seven weeks after reimplantation and contralateral nephrectomy, mean BUN levels were increased with longer duration of UUO. Interstitial expansion, fibrosis, and T-cell and macrophage infiltration were similar in kidneys harvested after 10 days of UUO or following 10 weeks of ureter reimplantation, suggesting that the inflammatory process persisted despite relief of obstruction. Urinary protein excretion after reimplantation was significantly increased compared to control animals. Our study shows that functional assessment of the formerly obstructed kidney can be made after reimplantation and may provide a useful model to test therapeutic strategies for reversing renal fibrosis and preserving or restoring renal function.

语种: 英语
WOS记录号: WOS:000254085100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64312
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Kings Coll London, Sch Med, Guys Hosp, Dept Nephrol & Transplantat, London E1 9RT, England
2.Kings Coll London, Sch Med, Kings Hosp, Dept Nephrol & Transplantat, London E1 9RT, England
3.Kings Coll London, Sch Med, St Thomas Hosp, Dept Nephrol & Transplantat, London E1 9RT, England
4.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China
5.Univ Newcastle Upon Tyne, Sch Clin Med Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

Recommended Citation:
Tapmeier, T. T.,Brown, K. L.,Tang, Z.,et al. Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation[J]. KIDNEY INTERNATIONAL,2008,73(7):885-889.
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