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Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation
Tapmeier, T. T.1,2,3; Brown, K. L.1,2,3; Tang, Z.1,2,3,4; Sacks, S. H.1,2,3; Sheerin, N. S.5; Wong, W.1,2,3
关键词renal fibrosis UUO reimplantation inflammation
刊名KIDNEY INTERNATIONAL
2008-04-01
DOI10.1038/sj.ki.5002797
73期:7页:885-889
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]MICE ; FIBROSIS ; RELIEF ; RATS
英文摘要

Experimental unilateral ureteral obstruction (UUO) is widely used to study renal fibrosis; however, renal injury can only be scored semiobjectively by histology. We sought to improve the UUO model by reimplanting the obstructed ureter followed by removal of the contralateral kidney, thus allowing longitudinal measurements of renal function. Mice underwent UUO for different lengths of time before ureteral reimplantation and contralateral nephrectomy. Measurement of blood urea nitrogen (BUN) allows objective evaluation of residual renal function. Seven weeks after reimplantation and contralateral nephrectomy, mean BUN levels were increased with longer duration of UUO. Interstitial expansion, fibrosis, and T-cell and macrophage infiltration were similar in kidneys harvested after 10 days of UUO or following 10 weeks of ureter reimplantation, suggesting that the inflammatory process persisted despite relief of obstruction. Urinary protein excretion after reimplantation was significantly increased compared to control animals. Our study shows that functional assessment of the formerly obstructed kidney can be made after reimplantation and may provide a useful model to test therapeutic strategies for reversing renal fibrosis and preserving or restoring renal function.

语种英语
WOS记录号WOS:000254085100016
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64312
专题北京大学第三临床医学院_肾内科
作者单位1.Kings Coll London, Sch Med, Guys Hosp, Dept Nephrol & Transplantat, London E1 9RT, England
2.Kings Coll London, Sch Med, Kings Hosp, Dept Nephrol & Transplantat, London E1 9RT, England
3.Kings Coll London, Sch Med, St Thomas Hosp, Dept Nephrol & Transplantat, London E1 9RT, England
4.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China
5.Univ Newcastle Upon Tyne, Sch Clin Med Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
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GB/T 7714
Tapmeier, T. T.,Brown, K. L.,Tang, Z.,et al. Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation[J]. KIDNEY INTERNATIONAL,2008,73(7):885-889.
APA Tapmeier, T. T.,Brown, K. L.,Tang, Z.,Sacks, S. H.,Sheerin, N. S.,&Wong, W..(2008).Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation.KIDNEY INTERNATIONAL,73(7),885-889.
MLA Tapmeier, T. T.,et al."Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation".KIDNEY INTERNATIONAL 73.7(2008):885-889.
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