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学科主题: 临床医学
题名:
Serologic autoimmunologic parameters in women with primary ovarian insufficiency
作者: Zhen, Xiumei1,2,3; Qiao, Jie1,2,3; Li, Rong1,2,3; Wang, Lina1,2,3; Liu, Ping1,2,3
关键词: Primary ovarian insufficiency ; Antibody ; Immune ; Microarray ; Premature ovarian failure
刊名: BMC IMMUNOLOGY
发表日期: 2014-03-10
DOI: 10.1186/1471-2172-15-11
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: FAILURE ; ANTIBODIES ; DISEASE ; ANTI-JO-1 ; AUTOANTIBODIES ; IDENTIFICATION ; PELLUCIDA
英文摘要:

Background: Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters.

Methods: The serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren′s syndrome A (SSA/Ro), Sjogren′s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA), Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA) were analyzed.

Results: Among the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.

Conclusions: This study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.

语种: 英语
所属项目编号: 20090001110090
项目资助者: Ministry of Education of China
WOS记录号: WOS:000332975500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64316
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China

Recommended Citation:
Zhen, Xiumei,Qiao, Jie,Li, Rong,et al. Serologic autoimmunologic parameters in women with primary ovarian insufficiency[J]. BMC IMMUNOLOGY,2014,15.
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