IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Serologic autoimmunologic parameters in women with primary ovarian insufficiency
Zhen, Xiumei1,2,3; Qiao, Jie1,2,3; Li, Rong1,2,3; Wang, Lina1,2,3; Liu, Ping1,2,3
关键词Primary ovarian insufficiency Antibody Immune Microarray Premature ovarian failure
刊名BMC IMMUNOLOGY
2014-03-10
DOI10.1186/1471-2172-15-11
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者Ministry of Education of China ; Ministry of Education of China
研究领域[WOS]Immunology
关键词[WOS]FAILURE ; ANTIBODIES ; DISEASE ; ANTI-JO-1 ; AUTOANTIBODIES ; IDENTIFICATION ; PELLUCIDA
英文摘要

Background: Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters.

Methods: The serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren′s syndrome A (SSA/Ro), Sjogren′s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA), Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA) were analyzed.

Results: Among the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.

Conclusions: This study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.

语种英语
所属项目编号20090001110090
资助者Ministry of Education of China ; Ministry of Education of China
WOS记录号WOS:000332975500001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64316
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhen, Xiumei,Qiao, Jie,Li, Rong,et al. Serologic autoimmunologic parameters in women with primary ovarian insufficiency[J]. BMC IMMUNOLOGY,2014,15.
APA Zhen, Xiumei,Qiao, Jie,Li, Rong,Wang, Lina,&Liu, Ping.(2014).Serologic autoimmunologic parameters in women with primary ovarian insufficiency.BMC IMMUNOLOGY,15.
MLA Zhen, Xiumei,et al."Serologic autoimmunologic parameters in women with primary ovarian insufficiency".BMC IMMUNOLOGY 15(2014).
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