IR@PKUHSC  > 北京大学公共卫生学院
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Combination of carotid intima-media thickness and plaque for better predicting risk of ischaemic cardiovascular events
Xie, Wuxiang1; Liang, Lirong2; Zhao, Liancheng3,4; Shi, Ping5; Yang, Ying6; Xie, Gaoqiang7; Huo, Yong6; Wu, Yangfeng1,7
刊名HEART
2011-08-01
DOI10.1136/hrt.2011.223032
97期:16页:1326-1331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者People&prime ; s Republic of China Ministry of Science and Technology ; Ministry of Health ; People&prime ; s Republic of China Ministry of Science and Technology ; Ministry of Health
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CORONARY-HEART-DISEASE ; REPUBLIC-OF-CHINA ; MYOCARDIAL-INFARCTION ; ATHEROSCLEROSIS RISK ; WALL THICKNESS ; ARTERIAL-WALL ; STROKE ; ADULTS ; POPULATION ; MEN
英文摘要

Background Several indices of carotid atherosclerosis have been studied to investigate their associations with the risk of cardiovascular disease. However, the best index of carotid atherosclerosis that predicts the risk of cardiovascular disease remains unclear.

Objective To investigate the index that best reflects the relationship between carotid atherosclerosis and subsequent ischaemic cardiovascular disease (ICVD) events.

Design An observational longitudinal study with a 5-year follow-up.

Participants 1734 Chinese subjects (623 men, 1111 women) aged 43-79 years at baseline.

Main outcome measures ICVD events, including coronary heart disease and ischaemic stroke.

Results Carotid intima-media thickness (IMT) at baseline was significantly associated with the risk of ICVD among participants without carotid plaque (multivariable adjusted HR=1.59, 95% CI 1.04 to 2.45) but not among those with plaque (HR=1.04, 95% CI 0.78 to 1.39). However, the total area of plaques (HR=1.29, 95% CI 1.08 to 1.55), the number of plaques (HR=1.14, 95% CI 1.02 to 1.27) and the number of segments with plaque (HR=1.45, 95% CI 1.09 to 1.93) were all significantly associated with ICVD in participants with plaque. Thus, carotid IMT and the number of segments with plaque were combined to establish a summary index-the total burden score (TBS) of carotid atherosclerosis-which was shown to improve the prediction of the 5-year risk of ICVD significantly compared with IMT or the number of segments with plaque alone. The c-statistics and net reclassification index showed that TBS improved the risk prediction by increases of 6.0% and 17.1%, respectively, compared with the conventional risk score.

Conclusion The TBS could significantly improve the prediction of ICVD risk and should be used in clinical practice and future studies.

语种英语
所属项目编号2001BA703B01 ; 2006BAI01A02
资助者People&prime ; s Republic of China Ministry of Science and Technology ; Ministry of Health ; People&prime ; s Republic of China Ministry of Science and Technology ; Ministry of Health
WOS记录号WOS:000292914900009
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64318
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
3.Chinese Acad Med Sci, Fuwai Hosp, Dept Epidemiol, Beijing 100730, Peoples R China
4.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100730, Peoples R China
5.Ctr Dis Prevent & Control, Dept Noncommunicable Dis Shijingshan, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100191, Peoples R China
7.Peking Univ, Clin Res Inst, Data Management Ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Xie, Wuxiang,Liang, Lirong,Zhao, Liancheng,et al. Combination of carotid intima-media thickness and plaque for better predicting risk of ischaemic cardiovascular events[J]. HEART,2011,97(16):1326-1331.
APA Xie, Wuxiang.,Liang, Lirong.,Zhao, Liancheng.,Shi, Ping.,Yang, Ying.,...&Wu, Yangfeng.(2011).Combination of carotid intima-media thickness and plaque for better predicting risk of ischaemic cardiovascular events.HEART,97(16),1326-1331.
MLA Xie, Wuxiang,et al."Combination of carotid intima-media thickness and plaque for better predicting risk of ischaemic cardiovascular events".HEART 97.16(2011):1326-1331.
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