|Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study|
|Zhao Yan2; Qiao Zheng-guo1; Shan Shi-jun3; Sun Qing-miao2; Zhang Jian-zhong1,2|
|关键词||glycoprotein non-metastatic melanoma protein B skin tumor tissue microarray|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||THERAPEUTIC TARGET ; BREAST-CANCER ; DC-HIL ; OSTEOACTIVIN ; CELLS ; METASTASIS ; ACTIVATION ; ADHESION ; GENES ; GPNMB|
Background Glycoprotein non-metastatic melanoma protein B (GPNMB) plays an important role in the pathogenesis of inflammatory and malignant diseases. We investigated the expression of GPNMB in benign and malignant skin diseases.
Methods Tissue microarray was performed in the skin tissues of 102 cases including malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and benign dermatosis. The expression of GPNMB in the tissues was detected by immunohistochemistry. Twenty cases of normal skin and adjacent neoplastic normal skin tissues were selected as controls.
Results GPNMB was positively stained in skin malignancies (38/50, 76%), which was significantly higher than that in the control and the benign skin tissues (P=0.001 and <0.001 respectively). GPNMB was positively stained in MM (13/15, 87%) and SCC (16/20, 80%) (P <0.001). Significant higher expression of GPNMB was observed in patients aged >= 65 years than those less than 65 years (n=11 and n=9 respectively, P=0.027). No significant difference of the expression rates was observed between normal control and BCC; however, stronger intensity was detected in the latter. Negative or weak expression was observed in the controls.
Conclusion Over-expression of GPNMB correlated strongly and might play an important role in the pathogenesis of MM and SOC. Chin Med J 2012;125(18):3279-3282
|作者单位||1.Peking Univ, Peoples Hosp, Dept Cent Lab, Beijing 100044, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
3.Tianjin Med Univ, Gen Hosp, Dept Dermatol, Tianjin 300052, Peoples R China
|Zhao Yan,Qiao Zheng-guo,Shan Shi-jun,et al. Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study[J]. CHINESE MEDICAL JOURNAL,2012,125(18):3279-3282.|
|APA||Zhao Yan,Qiao Zheng-guo,Shan Shi-jun,Sun Qing-miao,&Zhang Jian-zhong.(2012).Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study.CHINESE MEDICAL JOURNAL,125(18),3279-3282.|
|MLA||Zhao Yan,et al."Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study".CHINESE MEDICAL JOURNAL 125.18(2012):3279-3282.|