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学科主题: 基础医学
题名:
CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha
作者: Guo, Xiaohuan; Li, Ting; Wang, Yu; Shao, Luning; Zhang, Yingmei; Ma, Dalong; Han, Wenling
关键词: CMTM5 ; Pancreatic cancer ; Apoptosis ; TNF-alpha
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-09-11
DOI: 10.1016/j.bbrc.2009.06.148
卷: 387, 期:1, 页:139-142
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CLONING ; DEATH
英文摘要:

Our previous data show that CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is a potential tumor suppressor gene, but its function ill pancreatic cancer is Unknown. Herein we first report that CMTM5 is also absent in pancreatic cancer cell lines with promoter methylation. Compared with normal pancreatic tissues, CMTM5 is significantly decreased in cancer tissues. Restoration of CMTM5-v1 not only induces MIA PaCa-2 cell apoptosis with activation of caspase 3, 8 and 9. but also has synergistic effects with TNF-alpha. Thus, CMTM5 may play a role in the pancreatic cancer. (C) 2009 Elsevier Inc. All results reserved.

语种: 英语
所属项目编号: 30571691 ; 2006AA02A305 ; NCET-07-0013
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; New Century Excellent Talents in University
WOS记录号: WOS:000268736100025
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64326
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Ctr Human Dis Genom, Dept Immunol, Beijing 100191, Peoples R China

Recommended Citation:
Guo, Xiaohuan,Li, Ting,Wang, Yu,et al. CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,387(1):139-142.
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