学科主题基础医学
CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha
Guo, Xiaohuan; Li, Ting; Wang, Yu; Shao, Luning; Zhang, Yingmei; Ma, Dalong; Han, Wenling
关键词CMTM5 Pancreatic cancer Apoptosis TNF-alpha
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-09-11
DOI10.1016/j.bbrc.2009.06.148
387期:1页:139-142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CLONING ; DEATH
英文摘要

Our previous data show that CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is a potential tumor suppressor gene, but its function ill pancreatic cancer is Unknown. Herein we first report that CMTM5 is also absent in pancreatic cancer cell lines with promoter methylation. Compared with normal pancreatic tissues, CMTM5 is significantly decreased in cancer tissues. Restoration of CMTM5-v1 not only induces MIA PaCa-2 cell apoptosis with activation of caspase 3, 8 and 9. but also has synergistic effects with TNF-alpha. Thus, CMTM5 may play a role in the pancreatic cancer. (C) 2009 Elsevier Inc. All results reserved.

语种英语
WOS记录号WOS:000268736100025
项目编号30571691 ; 2006AA02A305 ; NCET-07-0013
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; New Century Excellent Talents in University
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64326
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学基础医学院
北京大学第三临床医学院_儿科
作者单位Peking Univ, Sch Basic Med Sci, Ctr Human Dis Genom, Dept Immunol, Beijing 100191, Peoples R China
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GB/T 7714
Guo, Xiaohuan,Li, Ting,Wang, Yu,et al. CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,387(1):139-142.
APA Guo, Xiaohuan.,Li, Ting.,Wang, Yu.,Shao, Luning.,Zhang, Yingmei.,...&Han, Wenling.(2009).CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,387(1),139-142.
MLA Guo, Xiaohuan,et al."CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 387.1(2009):139-142.
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