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Vanadyl bisacetylacetonate protects beta cells from palmitate-induced cell death through the unfolded protein response pathway
Gao, Zhonglan1,2; Zhang, Chengyue1,2; Yu, Siwang1,2; Yang, Xiaoda1,2; Wang, Kui1,2
关键词Vanadium Unfolded protein responses beta cell Free fatty acid Palmitate
刊名JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
2011-06-01
DOI10.1007/s00775-011-0780-0
16期:5页:789-798
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
资助者NSFC ; Research Fund for the Doctoral Program of Higher Education of China ; NSFC ; Research Fund for the Doctoral Program of Higher Education of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; OXIDATIVE STRESS ; DIABETIC-RATS ; FATTY-ACID ; ER STRESS ; INSULIN-SECRETION ; APOPTOSIS ; COMPLEXES ; GLUCOSE ; PERMEABILITY
英文摘要

Endoplasmic reticulum (ER) stress induced by free fatty acids (FFA) is important to beta-cell loss during the development of type 2 diabetes. To test whether vanadium compounds could influence ER stress and the responses in their mechanism of antidiabetic effects, we investigated the effects and the mechanism of vanadyl bisacetylacetonate [VO(acac)(2)] on beta cells upon treatment with palmitate, a typical saturated FFA. The experimental results showed that VO(acac)(2) could enhance FFA-induced signaling pathways of unfolded protein responses by upregulating the prosurvival chaperone immunoglobulin heavy-chain binding protein/78-kDa glucose-regulated protein and downregulating the expression of apoptotic C/EBP homologous protein, and consequently the reduction of insulin synthesis. VO(acac)(2) also ameliorated FFA-disturbed Ca(2+) homeostasis in beta cells. Overall, VO(acac)(2) enhanced stress adaption, thus protecting beta cells from palmitate-induced apoptosis. This study provides some new insights into the mechanisms of antidiabetic vanadium compounds.

语种英语
所属项目编号20971008
资助者NSFC ; Research Fund for the Doctoral Program of Higher Education of China ; NSFC ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号WOS:000290773500011
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64336
专题北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
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GB/T 7714
Gao, Zhonglan,Zhang, Chengyue,Yu, Siwang,et al. Vanadyl bisacetylacetonate protects beta cells from palmitate-induced cell death through the unfolded protein response pathway[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2011,16(5):789-798.
APA Gao, Zhonglan,Zhang, Chengyue,Yu, Siwang,Yang, Xiaoda,&Wang, Kui.(2011).Vanadyl bisacetylacetonate protects beta cells from palmitate-induced cell death through the unfolded protein response pathway.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,16(5),789-798.
MLA Gao, Zhonglan,et al."Vanadyl bisacetylacetonate protects beta cells from palmitate-induced cell death through the unfolded protein response pathway".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 16.5(2011):789-798.
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