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学科主题临床医学
Evaluation of Urinary Biomarkers for the Prognosis of Drug-associated Chronic Tubulointerstitial Nephritis
Shi, Yingjin1,2; Su, Tao1; Qu, Lei1; Wang, Caili2; Li, Xiaomei1; Yang, Li1
关键词Tubulointerstitial nephritis Prognosis Urinary biomarkers Matrix metalloproteinase N-acetyl--d-glucosaminidase
刊名AMERICAN JOURNAL OF THE MEDICAL SCIENCES
2013-10-01
DOI10.1097/MAJ.0b013e318271f910
346期:4页:283-288
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ACETYL-BETA-GLUCOSAMINIDASE ; TRANSFORMING GROWTH-FACTOR-BETA-1 ; MATRIX METALLOPROTEINASES ; IGA NEPHROPATHY ; KIDNEY ; PROTEINURIA ; FIBROSIS ; DISEASE ; GLOMERULONEPHRITIS ; ALBUMINURIA
英文摘要

Background:The efficacy of urinary biomarkers for predicting adverse clinical outcomes in drug-induced chronic tubulointerstitial nephritis (D-CTIN) has not been well described.Methods:A total of 54 patients with D-CTIN were prospectively followed-up in this study. The urinary excretion of 1-microglobulin and transforming growth factor-1 and the activity of urinary N-acetyl--d-glucosaminidase (NAG) and matrix metalloproteinases (MMPs) 2 and 9 at baseline were measured. Changes in the estimated glomerular filtration rate (GFR) over a period of 11 to 54 months (median, 38 months) of follow-up were recorded. The efficacy of urinary biomarkers for differentiating patients with various outcomes was tested. Ten patients with IgA nephropathy and 20 healthy volunteers were enrolled as controls.Results:The areas under the receiver operating characteristic curve for urinary NAG, MMP-9, MMP-2 and 1-microglobulin for predicting deterioration of the estimated GFR were 0.879, 0.867, 0.735 and 0.709, respectively (P < 0.05 for all). Partial regression coefficient results demonstrated that urinary NAG (P = 0.02), MMP-2 (P = 0.046) and MMP-9 (P = 0.041) were inversely correlated with the rate of GFR decline.Conclusions:Urinary NAG, MMP-2 and MMP-9 may be considered as possible candidates for forecasting the progression rate of D-CTIN.

语种英语
WOS记录号WOS:000326041000005
项目编号81070549
资助机构National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64338
专题北京大学第一临床医学院_肾脏内科
作者单位1.Baotou Med Coll, Affiliated Hosp 1, Div Renal, Baotou, Peoples R China
2.Peking Univ, Minist Hlth China, Key Lab Renal Dis, Dept Med,Inst Nephrol,Renal Div,Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Shi, Yingjin,Su, Tao,Qu, Lei,et al. Evaluation of Urinary Biomarkers for the Prognosis of Drug-associated Chronic Tubulointerstitial Nephritis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2013,346(4):283-288.
APA Shi, Yingjin,Su, Tao,Qu, Lei,Wang, Caili,Li, Xiaomei,&Yang, Li.(2013).Evaluation of Urinary Biomarkers for the Prognosis of Drug-associated Chronic Tubulointerstitial Nephritis.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,346(4),283-288.
MLA Shi, Yingjin,et al."Evaluation of Urinary Biomarkers for the Prognosis of Drug-associated Chronic Tubulointerstitial Nephritis".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 346.4(2013):283-288.
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