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学科主题临床医学
Levels of Urinary Complement Factor H in Patients with IgA Nephropathy are Closely Associated with Disease Activity
Zhang, J. -J.; Jiang, L.; Liu, G.; Wang, S. -X.; Zou, W. -Z.; Zhang, H.; Zhao, M. -H.
刊名SCANDINAVIAN JOURNAL OF IMMUNOLOGY
2009-05-01
DOI10.1111/j.1365-3083.2009.02234.x
69期:5页:457-464
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Natural Science Foundation of China ; Ministry of Health, People&prime ; s Republic of China ; &prime ; 985&prime ; project from Peking University and National Key Technology R D Programme ; People&prime ; s Republic of China ; National Natural Science Foundation of China ; Ministry of Health, People&prime ; s Republic of China ; &prime ; 985&prime ; project from Peking University and National Key Technology R D Programme ; People&prime ; s Republic of China
研究领域[WOS]Immunology
关键词[WOS]TUBULAR EPITHELIAL-CELLS ; BETA-1H GLOBULIN ; RENAL-DISEASE ; HUMAN-SERUM ; ACTIVATION ; PATHWAY ; BIOSYNTHESIS ; CHINA ; C3
英文摘要

Factor H plays a key inhibitory role in control of the activation of alternative pathway of complement system. The aim of the study was to investigate the predictive value of factor H as a biomarker of renal injury in IgA nephropathy (IgAN). Urine factor H concentration from 202 patients was measured and compared with that of 60 healthy volunteers. Forty-eight patients fulfilled Haas-I or II (group 1), 60 fulfilled Haas-III (group 2) and 94 fulfilled Haas-IV or V (group 3). Co-deposition of factor H and C3b in kidneys were investigated using confocal microscope. The levels of urinary factor H, when expressed as a ratio of urinary creatinine, were significantly higher in groups 3 than group 1 and 2, also significantly higher in group 2 than group 1. In addition, the levels of urinary factor H were significantly higher in those with factor H deposition in the kidney than those without deposition. The levels of urinary factor H may be a useful biomarker to evaluate kidney injury in IgAN.

语种英语
所属项目编号30570852 ; 2004230003 ; 2007BAI04B10
资助者National Natural Science Foundation of China ; Ministry of Health, People&prime ; s Republic of China ; &prime ; 985&prime ; project from Peking University and National Key Technology R D Programme ; People&prime ; s Republic of China ; National Natural Science Foundation of China ; Ministry of Health, People&prime ; s Republic of China ; &prime ; 985&prime ; project from Peking University and National Key Technology R D Programme ; People&prime ; s Republic of China
WOS记录号WOS:000265039300008
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64339
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Div Renal, Dept Med,Minist Hlth China, Hosp 1,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China
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GB/T 7714
Zhang, J. -J.,Jiang, L.,Liu, G.,et al. Levels of Urinary Complement Factor H in Patients with IgA Nephropathy are Closely Associated with Disease Activity[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY,2009,69(5):457-464.
APA Zhang, J. -J..,Jiang, L..,Liu, G..,Wang, S. -X..,Zou, W. -Z..,...&Zhao, M. -H..(2009).Levels of Urinary Complement Factor H in Patients with IgA Nephropathy are Closely Associated with Disease Activity.SCANDINAVIAN JOURNAL OF IMMUNOLOGY,69(5),457-464.
MLA Zhang, J. -J.,et al."Levels of Urinary Complement Factor H in Patients with IgA Nephropathy are Closely Associated with Disease Activity".SCANDINAVIAN JOURNAL OF IMMUNOLOGY 69.5(2009):457-464.
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