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学科主题临床医学
Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis
Gu, Xiaoguang; Wang, Yang; Zhang, Gaolei; Li, Weiwei; Tu, Ping
关键词mycosis fungoides BCL11B Hut78 interferon--2b methotrexate
刊名JOURNAL OF DERMATOLOGY
2013-08-01
DOI10.1111/1346-8138.12160
40期:8页:596-605
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
资助者National Nature Science Foundation of China ; Ministry of Education ; National Nature Science Foundation of China ; Ministry of Education
研究领域[WOS]Dermatology
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; T-CELL LYMPHOMA ; ALPHA-INDUCED APOPTOSIS ; SEZARY-SYNDROME ; UP-REGULATION ; CUTANEOUS-LYMPHOMAS ; THYMIC LYMPHOMAS ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; LYMPHOCYTES
英文摘要

BCL11B is a Kruppel-like C2H2-type zinc finger transcription factor, which has been associated with several human malignancies. Recent evidence showed that overexpressed BCL11B conferred chemoresistance to malignant cells and that inhibiting BCL11B led to increased apoptosis, suggesting its potential pathogenic relevance in cutaneous -cell lymphomas (C ), which were characterized by the resistance to chemotherapy-induced apoptosis. BCL11B in different stages of mycosis fungoides (MF), quantitative reverse transcription polymerase chain reaction and immunohistochemistry were performed to compare the mRNA and protein expression among different stages of MF and benign inflammatory dermatoses (BID), respectively. BCL11B demonstrated significant upregulation in all stages of MF, compared with BID, in both mRNA expression level and protein level. In addition, BCL11B expression increased with advancing lesion tumor stage and overall disease stage. Further, to evaluate the dynamic expression of BCL11B under C -directed treatment, BCL11B expression and cell apoptosis were evaluated after interferon (IFN)--2b and methotrexate treatment on C cell line Hut78 cells. IFN--2b, but not methotrexate, induced BCL11B inhibition and cell apoptosis, suggesting that BCL11B may play important roles in the anti-C effect of IFN--2b. In conclusion, our study demonstrated the overexpression of BCL11B in MF lesions and its potential relevance to disease progression. In addition, we provided evidence for BCL11B inhibitory approaches as a potential treatment to target chemoresistant tumor cells in advanced MF.

语种英语
所属项目编号81072233 ; 81201228 ; 20110001110027
资助者National Nature Science Foundation of China ; Ministry of Education ; National Nature Science Foundation of China ; Ministry of Education
WOS记录号WOS:000326243600027
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64341
专题北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Dept Dermatol & Venerol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Gu, Xiaoguang,Wang, Yang,Zhang, Gaolei,et al. Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis[J]. JOURNAL OF DERMATOLOGY,2013,40(8):596-605.
APA Gu, Xiaoguang,Wang, Yang,Zhang, Gaolei,Li, Weiwei,&Tu, Ping.(2013).Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis.JOURNAL OF DERMATOLOGY,40(8),596-605.
MLA Gu, Xiaoguang,et al."Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis".JOURNAL OF DERMATOLOGY 40.8(2013):596-605.
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