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学科主题: 临床医学
题名:
Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis
作者: Tan, Ying1,2,3,4; Song, Di1,2,3,4; Wu, Li-hua1,2,3,4,5; Yu, Feng1,2,3,4; Zhao, Ming-hui1,2,3,4
关键词: Lupus nephritis ; Anti-C1q autoantibodies ; Serum levels of C1q ; C1q depostion
刊名: BMC NEPHROLOGY
发表日期: 2013-03-19
DOI: 10.1186/1471-2369-14-63
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTI-C1Q ANTIBODIES ; IMMUNE-COMPLEXES ; DENDRITIC CELLS ; ERYTHEMATOSUS ; AUTOANTIBODIES ; CLASSIFICATION ; INTERFERON ; DEFICIENCY ; KIDNEY ; MICE
英文摘要:

Background: Lupus nephritis is considered to be a principal cause of morbidity and mortality in SLE. Few studies focus on the association between anti-C1q antibodies in circulation and renal C1q deposition in human lupus nephritis. In this study, we detected the serum levels of C1q, presence of anti-C1q antibodies in circulation, renal C1q deposition and further analyzed their associations with clinical and pathological activity in a large cohort of Chinese lupus nephritis patients.

Methods: Sera and renal biopsies from 218 consecutive patients with lupus nephritis with long-term follow up data were studied. Sera were tested for levels of C1q and anti-C1q autoantibodies. Associations of levels of C1q, anti-C1q autoantibodies with renal deposition of C1q, clinical and histopathological data and renal outcome were further investigated.

Results: The levels of serum C1q were significantly lower in lupus nephritis than that in normal controls [33.81 +/- 20.36 v.s. 61.97 +/- 10.50 mu g/ml (P < 0.001)]. The prevalence of anti-C1q antibodies, ratios of glomerular and vascular deposition of C1q in patients with lupus nephritis were 42.7% (93/218), 71.6% (156/218) and 86.2% (188/218), respectively. The serum C1q levels and anti-C1q antibodies were associated with SLEDAI scores (P < 0.001, P = 0.012, respectively), renal total activity indices scores (P < 0.001, P < 0.001, respectively). Granular positive staining of C1q and IgG by immunofluorescence was co-localized almost completely along the glomerular capillary wall and mesangial areas. Patients with anti-C1q antibodies presented with significantly lower serum C1q levels than those without it (23.82 [0.60, 69.62] mu g/ml v.s. 37.36 [0.64, 82.83] mu g/ml, P < 0.001). The presence of anti-C1q antibodies was associated with the presence of glomerular C1q deposition (P < 0.001), but not with the presence of renal vascular C1q deposition (P = 0.203).

Conclusion: Anti-C1q autoantibodies were closely associated with serum levels of C1q and glomerular deposition of C1q. Kidney is at least one of the target organs of anti-C1q autoantibodies.

语种: 英语
所属项目编号: 2012CB517702 ; 81100497
项目资助者: Chinese 973 project ; National Natural Science Foundation of China
WOS记录号: WOS:000317072800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64342
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
5.Ningxia Med Univ, Gen Hosp, Dept Nephrol, Ningxia 750004, Peoples R China

Recommended Citation:
Tan, Ying,Song, Di,Wu, Li-hua,et al. Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis[J]. BMC NEPHROLOGY,2013,14.
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