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学科主题: 基础医学
题名:
Peripheral electric stimulation inhibits morphine-induced place preference in rats
作者: Wang, B; Luo, F; Xia, YQ; Han, JS
关键词: acupuncture ; conditioned place preference ; frequency dependence ; morphine ; opioid ; opioid addiction ; peripheral electric stimulation ; psychological dependence ; rewarding effect
刊名: NEUROREPORT
发表日期: 2000-04-07
卷: 11, 期:5, 页:1017-1020
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: IDENTIFIED FREQUENCIES ; CROSS-TOLERANCE ; ARCUATE NUCLEUS ; ELECTROACUPUNCTURE ; REINFORCEMENT ; ANALGESIA ; REWARD ; BRAIN
英文摘要:

Conditioned place preference (CPP) is a commonly used model to detect rewarding effect of drugs. To observe the effect of peripheral electric stimulation (PES) on morphine-induced CPP, we trained the rats with morphine in a CPP paradigm. Twelve hours before the testing phase, rats were given PES via stainless-steel needles with frequencies of 2, 100, or 2/100 Hz, respectively. PES of 2 and 2/100 Hz significantly decreased CPP in morphine-trained animals in a naloxone reversible manner. while PES of 100 Hz, foot shock, needle insertion, or plain restraining, showed no effect. Thus, PES with a low-frequency component (2 Hz) could specifically inhibit the expression of morphine-induced CPP, presumably via activation of opioid receptors. NeuroReport 11:1017-1020 (C) 2000 Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000086385300028
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64348
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Wang, B,Luo, F,Xia, YQ,et al. Peripheral electric stimulation inhibits morphine-induced place preference in rats[J]. NEUROREPORT,2000,11(5):1017-1020.
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