IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Peripheral electric stimulation inhibits morphine-induced place preference in rats
Wang, B; Luo, F; Xia, YQ; Han, JS
关键词acupuncture conditioned place preference frequency dependence morphine opioid opioid addiction peripheral electric stimulation psychological dependence rewarding effect
刊名NEUROREPORT
2000-04-07
11期:5页:1017-1020
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]IDENTIFIED FREQUENCIES ; CROSS-TOLERANCE ; ARCUATE NUCLEUS ; ELECTROACUPUNCTURE ; REINFORCEMENT ; ANALGESIA ; REWARD ; BRAIN
英文摘要

Conditioned place preference (CPP) is a commonly used model to detect rewarding effect of drugs. To observe the effect of peripheral electric stimulation (PES) on morphine-induced CPP, we trained the rats with morphine in a CPP paradigm. Twelve hours before the testing phase, rats were given PES via stainless-steel needles with frequencies of 2, 100, or 2/100 Hz, respectively. PES of 2 and 2/100 Hz significantly decreased CPP in morphine-trained animals in a naloxone reversible manner. while PES of 100 Hz, foot shock, needle insertion, or plain restraining, showed no effect. Thus, PES with a low-frequency component (2 Hz) could specifically inhibit the expression of morphine-induced CPP, presumably via activation of opioid receptors. NeuroReport 11:1017-1020 (C) 2000 Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000086385300028
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64348
Collection北京大学基础医学院_神经生物学系
作者单位Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, B,Luo, F,Xia, YQ,et al. Peripheral electric stimulation inhibits morphine-induced place preference in rats[J]. NEUROREPORT,2000,11(5):1017-1020.
APA Wang, B,Luo, F,Xia, YQ,&Han, JS.(2000).Peripheral electric stimulation inhibits morphine-induced place preference in rats.NEUROREPORT,11(5),1017-1020.
MLA Wang, B,et al."Peripheral electric stimulation inhibits morphine-induced place preference in rats".NEUROREPORT 11.5(2000):1017-1020.
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