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Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers
Cheng, X. -J.1; Xu, W.2; Zhang, Q. -Y.1; Zhou, R. -L.3
关键词colorectal cancer esophageal cancer LAPTM4B polymorphism susceptibility
刊名ANNALS OF ONCOLOGY
2008-03-01
DOI10.1093/annonc/mdm469
19期:3页:527-532
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; DEPENDENT KINASE ; SH3 DOMAINS ; CYCLIN-E ; PROTEIN ; PROLINE ; BINDING ; IDENTIFICATION ; LYSOSOMES ; YEAST
英文摘要

Background: Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is a novel gene of the mammalian LAPTM family and has been shown to be overexpressed in human hepatocellular carcinoma. There are two alleles, LAPTM4B*1 and *2, which share the same sequence except for one segment of 19 bp in the 5′ untranslated region of the exon 1. LAPTM4B*1 has one 19 bp segment, while LAPTM4B*2 has two tight tandem segments. The current case-control study was aimed to identify relationship between the gene polymorphism of LAPTM4B and the susceptibility of colorectal and esophageal cancers.

Patients and methods: Blood samples were collected from patients with colon, rectal or esophageal cancers and control subjects. Genotypes of LAPTM4B were determined by PCR to detect differences between cancer cases (n = 701) and healthy controls (n = 350). Association between the LAPTM4B polymorphism and the risk of cancer was calculated by unconditional logistic regression models.

Results: We found that there was a significant difference (P = 0.0016) in allelic frequencies of LAPTM4B*2 between colon cancer cases (33.2%) and controls (24.1%). The risk of colon cancer was elevated significantly in cases with *1/2 genotype [odds ratio (OR) = 1.474; 95% confidence interval (CI) = 1.037-2.095] and *2/2 genotype (OR = 2.531; 95% CI = 1.316-4.868) when compared with the *1/1 genotype. No significant difference was observed for LAPTM4B*2 between the rectal or esophageal cancer cases when compared with the controls. The polymorphism in LAPTM4B was associated with increased risk of colon cancer but not of rectal and esophageal cancers.

Conclusions: These results indicate that the genetic polymorphism of LAPTM4B is a potential risk factor for the development of colon cancer.

语种英语
WOS记录号WOS:000253746200019
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64356
专题北京大学临床肿瘤学院_临床实验室
作者单位1.Peking Univ, Beijing Canc Hosp & Inst, Sch Med, Dept Clin Lab, Beijing 100036, Peoples R China
2.Bei Hua Univ, Sch Med, Beijing, Jilin, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China
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Cheng, X. -J.,Xu, W.,Zhang, Q. -Y.,et al. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers[J]. ANNALS OF ONCOLOGY,2008,19(3):527-532.
APA Cheng, X. -J.,Xu, W.,Zhang, Q. -Y.,&Zhou, R. -L..(2008).Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers.ANNALS OF ONCOLOGY,19(3),527-532.
MLA Cheng, X. -J.,et al."Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers".ANNALS OF ONCOLOGY 19.3(2008):527-532.
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