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学科主题: 临床医学
题名:
Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers
作者: Cheng, X. -J.1; Xu, W.2; Zhang, Q. -Y.1; Zhou, R. -L.3
关键词: colorectal cancer ; esophageal cancer ; LAPTM4B ; polymorphism ; susceptibility
刊名: ANNALS OF ONCOLOGY
发表日期: 2008-03-01
DOI: 10.1093/annonc/mdm469
卷: 19, 期:3, 页:527-532
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; DEPENDENT KINASE ; SH3 DOMAINS ; CYCLIN-E ; PROTEIN ; PROLINE ; BINDING ; IDENTIFICATION ; LYSOSOMES ; YEAST
英文摘要:

Background: Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is a novel gene of the mammalian LAPTM family and has been shown to be overexpressed in human hepatocellular carcinoma. There are two alleles, LAPTM4B*1 and *2, which share the same sequence except for one segment of 19 bp in the 5′ untranslated region of the exon 1. LAPTM4B*1 has one 19 bp segment, while LAPTM4B*2 has two tight tandem segments. The current case-control study was aimed to identify relationship between the gene polymorphism of LAPTM4B and the susceptibility of colorectal and esophageal cancers.

Patients and methods: Blood samples were collected from patients with colon, rectal or esophageal cancers and control subjects. Genotypes of LAPTM4B were determined by PCR to detect differences between cancer cases (n = 701) and healthy controls (n = 350). Association between the LAPTM4B polymorphism and the risk of cancer was calculated by unconditional logistic regression models.

Results: We found that there was a significant difference (P = 0.0016) in allelic frequencies of LAPTM4B*2 between colon cancer cases (33.2%) and controls (24.1%). The risk of colon cancer was elevated significantly in cases with *1/2 genotype [odds ratio (OR) = 1.474; 95% confidence interval (CI) = 1.037-2.095] and *2/2 genotype (OR = 2.531; 95% CI = 1.316-4.868) when compared with the *1/1 genotype. No significant difference was observed for LAPTM4B*2 between the rectal or esophageal cancer cases when compared with the controls. The polymorphism in LAPTM4B was associated with increased risk of colon cancer but not of rectal and esophageal cancers.

Conclusions: These results indicate that the genetic polymorphism of LAPTM4B is a potential risk factor for the development of colon cancer.

语种: 英语
WOS记录号: WOS:000253746200019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64356
Appears in Collections:北京大学临床肿瘤学院_临床实验室_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp & Inst, Sch Med, Dept Clin Lab, Beijing 100036, Peoples R China
2.Bei Hua Univ, Sch Med, Beijing, Jilin, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China

Recommended Citation:
Cheng, X. -J.,Xu, W.,Zhang, Q. -Y.,et al. Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers[J]. ANNALS OF ONCOLOGY,2008,19(3):527-532.
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