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学科主题: 基础医学
题名:
Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test
作者: Cui, X. -Y.; Zhao, X.; Chu, Q. -P.; Chen, B. -Q.; Zhang, Y. -H.
关键词: zolpidem ; mCPP ; diltiazem ; serotonergic system ; elevated plus-maze
刊名: JOURNAL OF NEURAL TRANSMISSION
发表日期: 2007-02-01
DOI: 10.1007/s00702-006-0535-1
卷: 114, 期:2, 页:155-160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BENZODIAZEPINE-RECEPTOR LIGANDS ; CALCIUM-CHANNEL ANTAGONISTS ; 5-HT2C RECEPTORS ; NONBENZODIAZEPINE HYPNOTICS ; ETHANOL WITHDRAWAL ; INDUCED ANXIETY ; RATS ; FLUMAZENIL ; MODELS ; AGENTS
英文摘要:

The present study was undertaken to investigate the effect of diltiazem, a L-type calcium channel blocker (CCB), on the behavior of zolpidem-treated mice in the elevated plus-maze (EPM). Atypical benzodiazepine zolpidem significantly increased the percentage of open arm entries without influencing the total entries and total distance and average speed at the dose of 5 mg/kg (p.o.). Co-administration of zolpidem (2 mg/kg, p.o.) and diltiazem (5, 10 and 20 mg/kg, p.o.) significantly increased both the time spent and arm entries in the open arms without influencing the total entries and spontaneous activity notwithstanding that zolpidem at dose up to 2 mg/kg (p.o.) and diltiazem at dose up to 20 mg/kg (p.o.) did not show any effects on mice behavior in EPM. Zolpidem also attenuated the anxiogenic effect of 1-(3-Chlorophenyl)piperazine (mCPP, 0.7 mg/kg, i.p.) and 5-hydroxytryptophan (5-HTP, 30 mg/kg, i.p.). Even though the zolpidem at 1 mg/kg and diltiazem at 5 mg/kg were ineffective on mCPP-induced anxiety, respectively, the co-administration of zolpidem (1 mg/kg, i.p.) and diltiazem (5 mg/kg, p.o.) showed inhibitory effect on mCPP-induced anxiety in mice. These results suggested that diltiazem, a L-type CCB may augment the anxiolytic-like effect of zolpidem and also indicated that calcium channel modulation maybe involved in the anxiolytic-like properties of zolpidem.

语种: 英语
WOS记录号: WOS:000243616000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64359
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Cui, X. -Y.,Zhao, X.,Chu, Q. -P.,et al. Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test[J]. JOURNAL OF NEURAL TRANSMISSION,2007,114(2):155-160.
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