北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 药理学系  > 期刊论文
学科主题: 基础医学
题名:
Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test
作者: Cui, X. -Y.; Zhao, X.; Chu, Q. -P.; Chen, B. -Q.; Zhang, Y. -H.
关键词: zolpidem ; mCPP ; diltiazem ; serotonergic system ; elevated plus-maze
刊名: JOURNAL OF NEURAL TRANSMISSION
发表日期: 2007-02-01
DOI: 10.1007/s00702-006-0535-1
卷: 114, 期:2, 页:155-160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BENZODIAZEPINE-RECEPTOR LIGANDS ; CALCIUM-CHANNEL ANTAGONISTS ; 5-HT2C RECEPTORS ; NONBENZODIAZEPINE HYPNOTICS ; ETHANOL WITHDRAWAL ; INDUCED ANXIETY ; RATS ; FLUMAZENIL ; MODELS ; AGENTS
英文摘要:

The present study was undertaken to investigate the effect of diltiazem, a L-type calcium channel blocker (CCB), on the behavior of zolpidem-treated mice in the elevated plus-maze (EPM). Atypical benzodiazepine zolpidem significantly increased the percentage of open arm entries without influencing the total entries and total distance and average speed at the dose of 5 mg/kg (p.o.). Co-administration of zolpidem (2 mg/kg, p.o.) and diltiazem (5, 10 and 20 mg/kg, p.o.) significantly increased both the time spent and arm entries in the open arms without influencing the total entries and spontaneous activity notwithstanding that zolpidem at dose up to 2 mg/kg (p.o.) and diltiazem at dose up to 20 mg/kg (p.o.) did not show any effects on mice behavior in EPM. Zolpidem also attenuated the anxiogenic effect of 1-(3-Chlorophenyl)piperazine (mCPP, 0.7 mg/kg, i.p.) and 5-hydroxytryptophan (5-HTP, 30 mg/kg, i.p.). Even though the zolpidem at 1 mg/kg and diltiazem at 5 mg/kg were ineffective on mCPP-induced anxiety, respectively, the co-administration of zolpidem (1 mg/kg, i.p.) and diltiazem (5 mg/kg, p.o.) showed inhibitory effect on mCPP-induced anxiety in mice. These results suggested that diltiazem, a L-type CCB may augment the anxiolytic-like effect of zolpidem and also indicated that calcium channel modulation maybe involved in the anxiolytic-like properties of zolpidem.

语种: 英语
WOS记录号: WOS:000243616000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64359
Appears in Collections:基础医学院_药理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Cui, X. -Y.,Zhao, X.,Chu, Q. -P.,et al. Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test[J]. JOURNAL OF NEURAL TRANSMISSION,2007,114(2):155-160.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cui, X. -Y.]'s Articles
[Zhao, X.]'s Articles
[Chu, Q. -P.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cui, X. -Y.]‘s Articles
[Zhao, X.]‘s Articles
[Chu, Q. -P.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace