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学科主题: 临床医学
题名:
Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation
作者: Ke, Hengte3; Wang, Jinrui1,2; Tong, Sheng4,5; Jin, Yushen3; Wang, Shumin1,2; Qu, Enze1,2; Bao, Gang4,5; Dai, Zhifei1,2
关键词: Liquid perfluorocarbon nanocapules ; Superparamagnetic iron oxide nanoparticles ; Gold nanoshell ; Bimodal imaging ; Photothermal therapy
刊名: THERANOSTICS
发表日期: 2014
DOI: 10.7150/thno.7275
卷: 4, 期:1, 页:12-23
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: IRON-OXIDE NANOPARTICLES ; MACROPHAGE ENDOCYTOSIS ; CANCER-THERAPY ; IN-VIVO ; SURFACES ; SURGERY ; AGENTS ; MRI
英文摘要:

Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.

语种: 英语
所属项目编号: 81225011 ; 81230036 ; 21273014
项目资助者: National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
WOS记录号: WOS:000331402100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64363
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Nanomed & Biosensor Lab, Harbin 150001, Peoples R China
4.Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA
5.Emory Univ, Atlanta, GA 30332 USA

Recommended Citation:
Ke, Hengte,Wang, Jinrui,Tong, Sheng,et al. Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation[J]. THERANOSTICS,2014,4(1):12-23.
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