IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation
Ke, Hengte3; Wang, Jinrui1,2; Tong, Sheng4,5; Jin, Yushen3; Wang, Shumin1,2; Qu, Enze1,2; Bao, Gang4,5; Dai, Zhifei1,2
关键词Liquid perfluorocarbon nanocapules Superparamagnetic iron oxide nanoparticles Gold nanoshell Bimodal imaging Photothermal therapy
刊名THERANOSTICS
2014
DOI10.7150/thno.7275
4期:1页:12-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China ; National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]IRON-OXIDE NANOPARTICLES ; MACROPHAGE ENDOCYTOSIS ; CANCER-THERAPY ; IN-VIVO ; SURFACES ; SURGERY ; AGENTS ; MRI
英文摘要

Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.

语种英语
所属项目编号81225011 ; 81230036 ; 21273014
资助者National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China ; National Natural Science Foundation for Distinguished Young Scholars ; State Key Program of National Natural Science of China ; National Natural Science Foundation of China
WOS记录号WOS:000331402100002
Citation statistics
Cited Times:69[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64363
Collection北京大学第三临床医学院
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Nanomed & Biosensor Lab, Harbin 150001, Peoples R China
4.Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA
5.Emory Univ, Atlanta, GA 30332 USA
Recommended Citation
GB/T 7714
Ke, Hengte,Wang, Jinrui,Tong, Sheng,et al. Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation[J]. THERANOSTICS,2014,4(1):12-23.
APA Ke, Hengte.,Wang, Jinrui.,Tong, Sheng.,Jin, Yushen.,Wang, Shumin.,...&Dai, Zhifei.(2014).Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation.THERANOSTICS,4(1),12-23.
MLA Ke, Hengte,et al."Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation".THERANOSTICS 4.1(2014):12-23.
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