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学科主题临床医学
Impact of pH on the antifungal susceptibility of vaginal Candida albicans
Liu, Wei1,2; Zhang, Xu1; Liu, Zhaohui1; Luo, Xin2
关键词Antifungal susceptibility Candida albicans pH
刊名INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
2011-09-01
DOI10.1016/j.ijgo.2011.03.016
114期:3页:278-280
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]MG
英文摘要

Objective: To investigate the antifungal susceptibility at pH 7.0 and pH 4.0 of 5 antifungal agents against Candida albicans isolated from patients with vulvovaginal candidiasis. Methods: Antifungal susceptibility testing at pH 7.0 and pH 4.0 was performed using the broth microdilution method (CISI, document M27-A2). Results: The minimal inhibitory concentrations (MICs) of miconazole, clotrimazole, fluconazole, and nystatin against C. albicans at pH 4.0 were significantly higher than those at pH 7.0 (0.25 vs 0.03 mu g/mL, 0.50 vs 0.03 mu g/mL, 0.50 vs 0.25 mu g/mL, and 32 vs 2 mu g/mL, respectively; P<0.001), whereas the MIC of itraconazole at pH 4.0 was lower than that at pH 7.0 (0.030 vs 0.125 mu g/mL; P<0.001). The susceptibility rate of C albicans to itraconazole at pH 4.0 was significantly higher than at pH 7.0 (95.0% vs 51.7%; P<0.001). The susceptibility rate to itraconazole at pH 7.0 was significantly lower than the susceptibility rate to fluconazole (51.7% vs 100.0%; P<0.001), whereas the susceptibility rates to the 2 drugs were similar at pH 4.0 (95.0% and 96.7%, respectively). Conclusion: Media at different pH values should be used for sensitivity tests according to the environment of C. albicans. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. on behalf of International Federation of Gynecology and Obstetrics. All rights reserved.

语种英语
WOS记录号WOS:000294397400019
资助机构Department of Obstetrics and Gynecology of Peking University First Hospital
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64364
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Jinan Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Liu, Wei,Zhang, Xu,Liu, Zhaohui,et al. Impact of pH on the antifungal susceptibility of vaginal Candida albicans[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2011,114(3):278-280.
APA Liu, Wei,Zhang, Xu,Liu, Zhaohui,&Luo, Xin.(2011).Impact of pH on the antifungal susceptibility of vaginal Candida albicans.INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,114(3),278-280.
MLA Liu, Wei,et al."Impact of pH on the antifungal susceptibility of vaginal Candida albicans".INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 114.3(2011):278-280.
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