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学科主题: 临床医学
题名:
Impact of pH on the antifungal susceptibility of vaginal Candida albicans
作者: Liu, Wei1,2; Zhang, Xu1; Liu, Zhaohui1; Luo, Xin2
关键词: Antifungal susceptibility ; Candida albicans ; pH
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
发表日期: 2011-09-01
DOI: 10.1016/j.ijgo.2011.03.016
卷: 114, 期:3, 页:278-280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: MG
英文摘要:

Objective: To investigate the antifungal susceptibility at pH 7.0 and pH 4.0 of 5 antifungal agents against Candida albicans isolated from patients with vulvovaginal candidiasis. Methods: Antifungal susceptibility testing at pH 7.0 and pH 4.0 was performed using the broth microdilution method (CISI, document M27-A2). Results: The minimal inhibitory concentrations (MICs) of miconazole, clotrimazole, fluconazole, and nystatin against C. albicans at pH 4.0 were significantly higher than those at pH 7.0 (0.25 vs 0.03 mu g/mL, 0.50 vs 0.03 mu g/mL, 0.50 vs 0.25 mu g/mL, and 32 vs 2 mu g/mL, respectively; P<0.001), whereas the MIC of itraconazole at pH 4.0 was lower than that at pH 7.0 (0.030 vs 0.125 mu g/mL; P<0.001). The susceptibility rate of C albicans to itraconazole at pH 4.0 was significantly higher than at pH 7.0 (95.0% vs 51.7%; P<0.001). The susceptibility rate to itraconazole at pH 7.0 was significantly lower than the susceptibility rate to fluconazole (51.7% vs 100.0%; P<0.001), whereas the susceptibility rates to the 2 drugs were similar at pH 4.0 (95.0% and 96.7%, respectively). Conclusion: Media at different pH values should be used for sensitivity tests according to the environment of C. albicans. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. on behalf of International Federation of Gynecology and Obstetrics. All rights reserved.

语种: 英语
项目资助者: Department of Obstetrics and Gynecology of Peking University First Hospital
WOS记录号: WOS:000294397400019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64364
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Jinan Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Liu, Wei,Zhang, Xu,Liu, Zhaohui,et al. Impact of pH on the antifungal susceptibility of vaginal Candida albicans[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2011,114(3):278-280.
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